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Electrophysiological effects of labetalol on canine atrial cardiac purkinje fibers and ventricular muscle


, : Electrophysiological effects of labetalol on canine atrial cardiac purkinje fibers and ventricular muscle. British Journal of Pharmacology 92(3): 627-634

1 Using conventional microelectrode techniques for the intracellular recordings of the membrane potential, the effects of labetalol were studied on cardiac Purkinje, atrial and ventricular muscle fibres of the dog. 2 Labetalol (1-10 .mu.M) reduced, in a concentration-dependent manner, the action potential amplitude (APA) and the maximum rate of rise of the action potential (Vmax) in Purkinje fibres. 3 The action potential duration (APD) was decreased in Purkinje fibres but significantly increased in ventricular fibres after small concentrations of labetalol (1-3 .mu.M). The atrial fibres were not very sensitive to labetalol. 4 Depolarization of the cardiac Purkinje fibres by increasing the external potassium concentration (8-12 mM), potentiated the labetalol effects on APA and Vmax but blocked its effects on the APD. 5 The effects of labetalol on Vmax of Purkinje fibres were dependent on the frequency of stimulation. 6 The ratio of the effective refractory period to the APD was increased both in normally polarized and depolarized Purkinje fibres after treatment with labetalol (10 .mu.M). 7 Labetalol (10 .mu.M) shifted the membrane responsiveness curve of Purkinje fibres by about 10 mV in the hyperpolarizing direction. 8 The slow response obtained in K-depolarized, Ba-treated Purkinje fibres was not significantly affected by labetalol (10-100 .mu.M). 9 It is suggested that labetalol can exert Class I and Class III antiarrhythmic actions in cardiac muscle of the dog in vitro.

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McCraw, David J., 2008: Preliminary geologic map of the South Spring 75-minute quadrangle map, Chaves County, New Mexico. Open-File Geologic Map Series: 21, 1 sheet. New Mexico Bureau of Geology and Mineral Resources.

Stroffolini T.; De Mattia D.; Compagnone A.; Arcamone G.P.; Altomare M.; Schettini F., 1990: Age specific prevalence of hepatitis b virus infection among children in an endemic area in southern italy. In 1989 the prevalence of hepatitis B virus markers was studied by radioimmunoassay in a sample of 1426 healthy children, 3 to 11 years old, attending kindergarten and the primary schools in a large urban area of the Apulia Region in Southern Ital...

Mastoi,A.M.; Narejo,N.T.; Lashari,P.K.; Lal,M.; Mastoi,G.M., 2008: Some aspects of breeding biology of Dahi, Labeo calbasu from Keenjbar Lake , Sindh, Pakistan. Some aspects of breeding biology of Dahi, <i>Labeo calbasu</i> (Hamilton) from Keenjhar Lake (District Thatta), Sindh were studied in terms of sex dimorphism, gonadosomatic index (GSI), ova diameter and fecundity during (March 2006 to...

Lyubimov, G. A.; Skobeleva, I. M., 1992: Effect of the physical parameters of the lungs on the shape of the flow-volume curve of forced expiration. The results of the mathematical study of the dependence of the shape of the flow-volume curve and some other regularities associated with forced respiration on the physical parameters of the lungs. The model of the lungs is described. It was found...

Iwatsuki, Z.; Kiguchi, H.; Deguchi, H., 1986: Grimmia mollis bruch et schimp. occurs in japan. Grimmia mollis Bruch et Schimp. has been neglected in Japan although it was once reported as occurring in Japan by Sakurai (1954). Kiguchi, one of the authors, found the species on the rocks near a snow melt stream in the alpine region of Mt. Hoda...

Furuta G.T.; Bloss R.S.; Lifschitz C.H.; Khalil K.; Shulman R.J., 1989: Colonic interposition after esophagogastrectomy in a child with zollinger ellison syndrome. Journal of Pediatric Surgery 24(11): 1146-1148

Soderberg I.; Nicklasson A.; Christoffersson J.; Johannesson J., 1971: The flora of the mora valley with special regard to the bryophytes. Svensk Botanisk Tidskrift 65(4): 371-392

Anonymous, 2013: Obesity in Libya a review. Obesity is a global epidemic resulting in major morbidity and premature death. About 64% of Libyan adults are either overweight or obese, obesity progressively increasing with age, and two times more common among Libyan women than men. Cases of ob...

Iturralde, Pedro; Saucedo, Jorge; Colin, Luis; Kershenovich, Sergio; Robledo, Rogelio; Garrido, Armando; Gonzalez Hermosillo, Jesus Antonio; Buendia, Alfonso, 1994: Radiofrequency ablation of accessory pathway in children with supraventricular tachycardia. Archivos del Instituto de Cardiologia de Mexico 64(4): 349-354

Bocchio Rosangela; De Capitani Luisa; Ottolini Luisa; Cella Fiorenza, 2000: Trace element distribution in eclogites and their clinopyroxene/ garnet pair; a case study from Soazza (Switzerland). European Journal of Mineralogy 12(1): 147-161