+ Site Statistics
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Electrophysiological effects of tetracaine on the longitudinal muscle of rat uterus in various ionic environments

, : Electrophysiological effects of tetracaine on the longitudinal muscle of rat uterus in various ionic environments. Japanese Journal of Physiology 37(5): 851-869

Electrical activity was recorded intracellularly from the uterine longitudinal muscle of estrogen-treated rat. Membrane potential was -59 mV. Action potential consisted of initial spike and the following plateau potential on which repetitive spike discharge rode. Tetracaine (0.1, 0.2 mM) reduced the maximum rates of rise and fall of initial spike and increased the duration of plateau potential. Sustained depolarization at -33 mV was produced by the application of 0.8 mM tetracaine. The membrane depolarization was accompanied with the increase in membrane resistance. Reduction of initial spike by tetracaine in the maximum rates of rise and fall was prevented by increasing the external Ca concentration and accelerated by decreasing it. In low K (1.2 mM) or isoprenaline (10(-8) M)-containing solution, tetracaine-induced prolongation of plateau potential was inhibited. Plateau potential was reduced in amplitude and was prolonged only slightly by tetracaine in low Na solution (sucrose substitution). Both the initial spike and plateau potentials were blocked completely by 0.2 mM tetracaine in the presence of Mn (0.5 mM) or verapamil (0.5 microM). It is speculated that tetracaine suppresses the K conductances responsible for resting membrane potential and the repolarizations of spike and plateau potentials. Ca influx during the generation of action potential is also supposed to be inhibited by tetracaine.

(PDF 0-2 workdays service)

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 005349600

PMID: 3449665

PDF Full Text: Submit

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Severo, L.C.; Oliveira, F.M.; Irion, K.; Porto, N.S.; Londero, A.T., 2001: Histoplasmosis in Rio Grande do Sul, Brazil: a 21-year experience. Of 156 cases of histoplasmosis observed in the State of Rio Grande do Sul (Brazil), during a 21-year period (1978-1999) 137 were included in this study. Sixty-seven per cent of the patients had hematogeneous disseminated histoplasmosis, 24% had a...

Leclercq, J., 1957: Revision des Ectemnius du sous-genre Apoctemnius Leclercq,1950(Hym. Sphecidae Crabroninae). II.-Sur quatre especes sud-americaines. Bulletin et Annales de la Societe R Entomologique de Belgique, 93: 319-324

Wolinsky, Matthew A.; Murray, A. Brad, 2009: A unifying framework for shoreline migration; 2, Application to wave-dominated coasts. Journal of Geophysical Research 114.F1

Allen, M.J.; Drummond, J.A.; Moffat, K.G., 1998: Development of the giant fiber neuron of Drosophila melanogaster. The giant fiber system (GFS) of Drosophila melanogaster provides a convenient system in which to study neural development. It mediates escape behaviour through a small number of neurons, including the giant fibers (GFs), to innervate the tergotroc...

Garcia-Alcalde, J. L.; Alvarez, F., 1976: Taxonomic status of some species of brachiopods from the verneuil collection. Brachiopods derived from Devonian strata of the Cantabrian Mountains (northwest Spain) that were included in old collections of Verneuil which were lost, were found again in the Faculte des Sciences at Orsay (France). Some of them are designated a...

Marose, Stefan; Lindemann, Carsten; Hitzmann, Bernd; Pekeler, Thomas; Scheper, Thomas, 1997: 2-D fluorescence spectroscopy for on-line monitoring of cultivation processes. Abstracts of Papers American Chemical Society 213(1-3): BIOT 136

Hashimoto, Y., 1967: Studies of anticoagulant therapy in myocardial infarction. Ninety six hospltal cases with acute myocardial infarction were analyzed for factors important to prognosis. Linear discriminant analysis utilizing computers was used for evaluating the severity of illness in acute myocardial infarction. The predi...

Uoshima M.; Borgese D.A.; Kinoshita A.; Oda S.; Ishikawa I., 1992: Replacement of biphasic calcium phosphate by bone tissue in monkeys. Journal of Dental Research 71(SPEC ISSUE): 580

Chroust, K., 1996: Chronicle. Prof. MVDr. Vaclav Dyk, DSc. has died. Helminthologia (Bratislava). March; 331: 8

Armstrong, J. T., 1941: Grade herd-recordings, 1939-40. A TOTAL of 7819 cows from 317 herds completed their lactation periods during the year, average production per cow being 4877 Ib. of milk and 224.06 Ib. (4.5%) butter-fat. There was a marked variation between average yields of cows in the different...