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Electrophysiological interactions between haloperidol and reduced haloperidol and dopamine norepinephrine and phencyclidine in rat brain


, : Electrophysiological interactions between haloperidol and reduced haloperidol and dopamine norepinephrine and phencyclidine in rat brain. Neuropharmacology 24(5): 375-380

Haloperidol and its metabolite, reduced haloperidol, were compared as antagonists of catecholaminergic neurotransmission in the CNS of the rat. Agonists and antagonists were applied from multibarrelled micropipettes, which were also used to record extracellularly the effects of these substances on neuronal discharge. Haloperidol antagonized dopaminergic inhibition of caudate neurons and inhibition of cerebellar. Purkinje neurons induced by noradrenaline [norepinephrine] whereas reduced haloperidol was an ineffective antagonist. Phencyclidine, which is an indirect dopaminergic agonist in the caudate, caused inhibition of the discharges of caudate neurons resembling that induced by dopamine itself. These indirect effects of phencyclidine were also antagonized by haloperidol but not by reduced haloperidol. The metabolite, reduced haloperidol, is not an effective neuroleptic drug in the CNS.

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Accession: 005349675

PMID: 2862598

DOI: 10.1016/0028-3908(85)90021-8

PDF Full Text: Electrophysiological interactions between haloperidol and reduced haloperidol and dopamine norepinephrine and phencyclidine in rat brain


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Hadziselimovic, F.; Hocht, B.; Herzog, B.; Buser, M.W., 2007: Infertility in cryptorchidism is linked to the stage of germ cell development at orchidopexy. Background: Cryptorchidism represents the most common endocrine disease in boys, with infertility frequently observed in unilateral as well as bilateral forms. In this study, we examined the role of Ad ( dark) spermatogonia for fertility in crypt...

Kato, K.; Zhang, M-Rong.; Suzuki, K., 2007: Rapid C-carboxylation of nitro[(11)C]methane for the synthesis of ethyl nitro[2-(11)C]acetate. The labelling synthesis of ethyl nitro[2-(11)C]acetate, a synthetic intermediate feasible for (11)C-labelled PET tracers, by C-carboxylation of [(11)C]MeNO(2) with 1-ethoxycarbonylbenzotriazole, and its simple application are presented.

Csiszar, V., 1956: The sedimenting and pressure-diminishing milk filter and its experimental valuations. The strainer, presumably for use in the cowshed, includes a sedimentation element, in which the milk rises and overflows through a fine mesh in the wall at the top. This arrangement reduces the pressure on the filter and minimizes turbulence which...

Cranston, A.; Bocker, T.; Palazzo, J.; Fishel, R., 1999: Enhanced intestinal tumorigenesis in mice deficient for both Msh2 and Rag-1. Proceedings of the American Association for Cancer Research Annual Meeting 40: 350, March

Gaponova, L. P., 2008: The centrohelid heliozoans Protista, Centrohelida of algal mats from the water body in Ukrainian polissya. Pterocystis foliacea (Durrschmidt, 1985), Raineriophrys erinaceoides (Petersen et Hansen, 1960) and Acanthocystis dresscheri Siemensma et Roijackers, 1988 were observed in algal mats from the pond. All the three species are redescribed.

Szember, A.G.stkowska, K.F.rczak, J., 1974: The intensity of ammonification and nitrification in the soi l under legumes in monoculture and in crop rotation with con stant application of herbicides. I. Polish journal of soil science: ub 1974), 6 (2) 141-147

Irvine, E.E., 2013: Children in Kibbutzim: thirteen years after. The social system of the kibbutz is briefly described, especially as it affects the young child. Attention is paid to the distribution of parental functions between mother, nurse and father, and the conceptual problems involved in the analysis of...

Desroziers, G.; Bellan Santini, D.; Brethes, J C., 1984: Organisation trophique de la faune annelidienne de substrats rocheux, selon un gradient de pollution industrielle (golfe de Fos). Oceanis 10(7): 799-812

van der Beek, M.T.; Marijt, E.W.A.F.; Vossen, A.C.T.M.; van der Blij-de Brouwer, C.S.; Wolterbeek, R.; Halkes, C.J.M.; Claas, E.C.J.; Kroes, A.C.M., 2013: Failure of pre-emptive treatment of cytomegalovirus infections and antiviral resistance in stem cell transplant recipients. Treatment of cytomegalovirus (CMV) infections after stem cell transplantation (SCT) does not always lead to a rapid viral response. The causes of treatment failure may be either viral resistance or immunological failure to control viral replicatio...

Katsiyiannakis, E.; Giannaki, M.; Mirilla, I.; Bouzizi, P.; Bassanou, E.; Kassiou, K.; Charissiadou, A.; Mentis, A.; Pangalis, A., 2000: Antigen enzyme immunoassay in stool specimen for diagnosis and monitoring of Helicobacter pylori infection in children. JPGN 31(Supplement 2): S147