EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Electrophysiological interactions between haloperidol and reduced haloperidol and dopamine norepinephrine and phencyclidine in rat brain


Neuropharmacology 24(5): 375-380
Electrophysiological interactions between haloperidol and reduced haloperidol and dopamine norepinephrine and phencyclidine in rat brain
Haloperidol and its metabolite, reduced haloperidol, were compared as antagonists of catecholaminergic neurotransmission in the CNS of the rat. Agonists and antagonists were applied from multibarrelled micropipettes, which were also used to record extracellularly the effects of these substances on neuronal discharge. Haloperidol antagonized dopaminergic inhibition of caudate neurons and inhibition of cerebellar. Purkinje neurons induced by noradrenaline [norepinephrine] whereas reduced haloperidol was an ineffective antagonist. Phencyclidine, which is an indirect dopaminergic agonist in the caudate, caused inhibition of the discharges of caudate neurons resembling that induced by dopamine itself. These indirect effects of phencyclidine were also antagonized by haloperidol but not by reduced haloperidol. The metabolite, reduced haloperidol, is not an effective neuroleptic drug in the CNS.

Accession: 005349675

PMID: 2862598

DOI: 10.1016/0028-3908(85)90021-8

Download PDF Full Text: Electrophysiological interactions between haloperidol and reduced haloperidol and dopamine norepinephrine and phencyclidine in rat brain



Related references

The plasma haloperidol and reduced haloperidol concentrations in chinese schizophrenic patients relationship between reduced haloperidol haloperidol ratio and red blood cell haloperidol reductase activity. Human Psychopharmacology 7(2): 123-128, 1992

Simultaneous determination of haloperidol and reduced haloperidol by gas chromatography using a megabore column with electron-capture detection: application to microsomal oxidation of reduced haloperidol. Journal of Chromatography 529(1): 182-188, 1990

Simultaneous determination of haloperidol and reduced haloperidol by gas chromatography using a megabore column with electron capture detection application to microsomal oxidation of reduced haloperidol. Journal of Chromatography Biomedical Applications 529(1): 182-188, 1990

Reduced haloperidol effects on striatal dopamine metabolism and conversion to haloperidol in the rat. Psychopharmacology 83(1): 34-37, 1984

The measurement of haloperidol and reduced haloperidol in neonatal hair as an index of placental transfer of maternal haloperidol. Therapeutic Drug Monitoring 13(2): 183-187, 1991

Ketone reductase activity and reduced haloperidol/haloperidol ratios in haloperidol-treated schizophrenic patients. Psychiatry Research. 57(2): 101-108, 1995

Pharmacokinetics of haloperidol and reduced haloperidol in Chinese schizophrenic patients after intravenous and oral administration of haloperidol. Psychopharmacology 106(4): 517-522, 1992

Disposition of Haloperidol and Reduced Haloperidol Plasma Levels After Single Dose Haloperidol Decanoate Administration. Human Psychopharmacology. 10(1): 47-51, 1995

Plasma reduced haloperidol/haloperidol ratios in schizophrenic patients treated with high dosages of haloperidol. European Neuropsychopharmacology 4(2): 119-126, 1994

Haloperidol and reduced haloperidol plasma concentrations after a loading dose regimen with haloperidol decanoate. Progress In Neuro-Psychopharmacology & Biological Psychiatry. 20(1): 73-86, 1996