+ Site Statistics
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Electrophysiological properties of cultured dorsal root ganglion and spinal cord neurons of normal and trisomy 16 fetal mice

, : Electrophysiological properties of cultured dorsal root ganglion and spinal cord neurons of normal and trisomy 16 fetal mice. Developmental Brain Research 32(1): 111-122

Dorsal root ganglion (DRG) and spinal cord neurons from normal and trisomy 16 fetal mice, and animal model for human trisomy 21 (Down syndrome), were maintained in primary culture and their electrical membrane properties were compared with intracellular recording techniques. After 3-4 weeks in culture, trisome DRG neurons had a higher mean resting potential (+10%), a higher specific membrane resistance (+50%) and higher excitability (+17%), a shorter action potential (-22%), higher maximal rates of depolarization (+39%) and of two phases of repolarization (+20% and +10%) and a lower duration (-42%) of the afterhyperpolarization, than did control DRG neurons (P < 0.05). The duration of the action potential was 2 .times. greater than in control neurons, when external calcium was elevated from 1.2 to 10 mM. Differences in the electrical parameter like those observed in DRG neurons also were found in cultured spinal cord neurons. These results indicate that trisomy 16 in fetal mice alters passive and active electrical membrane properties in DRG and spinal cord neurons, and suggest that some differences are related to differences in calcium currents.

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 005349728

PMID: 2952222

DOI: 10.1016/0165-3806(87)90144-1

Download PDF Full Text: Electrophysiological properties of cultured dorsal root ganglion and spinal cord neurons of normal and trisomy 16 fetal mice

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Brien, J.; Klein, P., 2004: Design, development and manufacture of needle valves as bottom discharge valves for dams. At the Mohne reservoir, the second largest reservoir of the Ruhrverband Essen, Germany, considerable work of reconstruction as well as repair and maintenance had been done since 1992 until 2001. In connection with the reconstruction of the complet...

Carassou-Maillan, A.; Pouly, J-L.; Mulliez, A.; Dejou-Bouillet, L.; Gremeau, A-S.; Brugnon, F.; Janny, L.; Canis, M., 2015: Adverse pregnancy outcomes after Assisted Reproduction Technology in women with endometriosis. While association between endometriosis and infertility is well established, there are few studies about the impact of endometriosis on adverse pregnancy outcomes. The aim of this study was to determine the effect of endometriosis on obstetric out...

Cousin, M.-T.; Van Loon, L.C., 1965: The effect of the grafting date on the appearance of stolbur symptoms on tomatoes. Young tomato plants chip-budded with stolbur-infected material showed 80-100% transmission of the disease when grown under glass, but were much less susceptible in the open. Grafting within the first fortnight of planting out caused dwarfing and c...

Anikandrov, B.; Brzhozovskiĭ, A.G., 1972: Anton Grigor'evich Brzhozovskiĭ (on his 100th anniversary). Vestnik Khirurgii Imeni I. I. Grekova 107(1): 147-148

Hino, T.; Arai, K., 1989: Disintegration of visible light-cured composite resins caused by long-term water immersion. The purpose of this study is to clarify a cause of disintegration of composite resins by long-term immersion in distilled water. Three kinds of visible light-cured composite resins (Heliosit, Plurafil Super and Visio Dispers) and one conventional...

Zolnierowicz, S.; Cron, P.; Solinas Toldo, S.; Fries, R.; Lin, H.Y.; Lodish, H.F.; Hemmings, B.A., 1993: Calcitonin receptor gene Structure, characterization and chromosomal location. Experientia (Basel) 49(ABSTR ): A45

Agrati, C.; Gioia, C.; Soldani, F.; Martini, F.; Antinori, A.; Poccia, F., 2006: T cell selection and differentiation in AIDS disease: the model of HIV-discordant monozygotic twins. The model of monozygotic twins has been repeatedly studied to control the genetic and age-specific effects on HIV disease. Focusing on this natural model, the expression of CD27/CD45RA differentiation markers and the distribution of the V beta TCR...

Du, J.; Wu, Y.; Ai, Z.; Shi, X.; Chen, L.; Guo, Z., 2015: Mechanism of SB431542 in inhibiting mouse embryonic stem cell differentiation. SB431542 (SB) is an established small molecular inhibitor that specifically binds to the ATP binding domains of the activin receptor-like kinase receptors, ALK5, ALK4 and ALK7, and thus specifically inhibits Smad2/3 activation and blocks TGF-β si...

Grant, W.B., 2015: Vitamin D and cancer incidence--letter from Grant. Cancer Epidemiology, Biomarkers & Prevention 23(9): 1950-1950

Pan, S.; Taneja, V.; Griffiths, M., M.; Luthra, H.; David, C., S., 1999: Complementation between HLA-DR4 (DRB1*0401) and specific H2-A molecule in transgenic mice leads to collagen-induced arthritis. We generated transgenic mice with DRB1*0401 gene with mutation in the beta2 domain (aa 110 and 139) for better interaction with mCD4. The DR4 transgene was introduced into H2-Aq (B10RQB3) and H2-Af (B10RFB3) to examine the role of DR4 in collagen...