EurekaMag.com logo
+ Site Statistics
References:
48,253,228
Abstracts:
22,798,842
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Electrophysiological properties of cultured dorsal root ganglion and spinal cord neurons of normal and trisomy 16 fetal mice


, : Electrophysiological properties of cultured dorsal root ganglion and spinal cord neurons of normal and trisomy 16 fetal mice. Developmental Brain Research 32(1): 111-122

Dorsal root ganglion (DRG) and spinal cord neurons from normal and trisomy 16 fetal mice, and animal model for human trisomy 21 (Down syndrome), were maintained in primary culture and their electrical membrane properties were compared with intracellular recording techniques. After 3-4 weeks in culture, trisome DRG neurons had a higher mean resting potential (+10%), a higher specific membrane resistance (+50%) and higher excitability (+17%), a shorter action potential (-22%), higher maximal rates of depolarization (+39%) and of two phases of repolarization (+20% and +10%) and a lower duration (-42%) of the afterhyperpolarization, than did control DRG neurons (P < 0.05). The duration of the action potential was 2 .times. greater than in control neurons, when external calcium was elevated from 1.2 to 10 mM. Differences in the electrical parameter like those observed in DRG neurons also were found in cultured spinal cord neurons. These results indicate that trisomy 16 in fetal mice alters passive and active electrical membrane properties in DRG and spinal cord neurons, and suggest that some differences are related to differences in calcium currents.

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 005349728

PMID: 2952222

DOI: 10.1016/0165-3806(87)90144-1

PDF Full Text: Electrophysiological properties of cultured dorsal root ganglion and spinal cord neurons of normal and trisomy 16 fetal mice


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Kornisheva, V.G.; Sokolova, G.A., 2000: Focal alopecia and chronic candidiasis. Vestnik Dermatologii i Venerologii (4): 57-59

Michalski, K., 2007: Readers and authors respond to "introducing the doctor of nursing practice". Medgenmed 8(3): 84; Discussion 84-84; Discussion 84

Smela Mariusz, 1999: Numerical data bases for medicinal waters in Krynica. Przeglad Geologiczny: , Pages 591. 1999.

Kobilinsky, L.; Beattie, D.S., 1977: The reversibility of the ethidium bromide-induced alterations of mitochondrial structure and function in the cellular slime mold, Dictyostelium discoideum. Journal of Bioenergetics and Biomembranes 9(1): 73-90

Mudd, L.M.; Evenson, K.R., 2015: Review of impacts of physical activity on maternal metabolic health during pregnancy. Our purpose was to review relations between physical activity during pregnancy, gestational diabetes, and other maternal metabolic markers (i.e., lipids, tumor necrosis factor alpha (TNFα), interleukin six (IL-6), leptin, and adiponectin). While...

Shultz, P.L.; Mokler, D.; Galler, J.R.; Luebke, J., 1999: Prenatal protein malnutrition results in increased frequency of miniature inhibitory postsynaptic currents in rat CA1 pyramidal cells. Society for Neuroscience Abstracts 25(1-2): 2019

Rostova N.S.; Koval' S.F., 1986: Correlation structure of productivity elements in low growing isogenic lines of spring wheat. A comparative study was undertaken of the correlations between 10 yield components of isogenous lines and their analogues of spring common wheat with genes of short-stemness derived from Norin, Tom Puss cvs and square-headed Scale's mutant of...

Vandecasteele, I.; Marí Rivero, Iés.; Sala, S.; Baranzelli, C.; Barranco, R.; Batelaan, O.; Lavalle, C., 2016: Impact of shale gas development on water resources: a case study in northern poland. Shale gas is currently being explored in Europe as an alternative energy source to conventional oil and gas. There is, however, increasing concern about the potential environmental impacts of shale gas extraction by hydraulic fracturing (fracking)...

Hales, C.M.; Harpaz, R.; Ortega-Sanchez, I.; Bialek, S.R., 2014: Update on recommendations for use of herpes zoster vaccine. Herpes zoster vaccine (Zostavax [Merck &amp; Co., Inc.]) was licensed in 2006 and recommended by the Advisory Committee on Immunization Practices (ACIP) in 2008 for prevention of herpes zoster (shingles) and its complications among adults aged...

Hoosdally, S.J.; Andress, E.J.; Wooding, C.; Martin, C.A.; Linton, K.J., 2009: The Human Scavenger Receptor CD36: glycosylation status and its role in trafficking and function. Human CD36 is a class B scavenger receptor expressed in a variety of cell types such as macrophage and adipocytes. This plasma membrane glycoprotein has a wide range of ligands including oxidized low density lipoprotein and long chain fatty acids...