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Electrophysiological properties of cultured dorsal root ganglion and spinal cord neurons of normal and trisomy 16 fetal mice


, : Electrophysiological properties of cultured dorsal root ganglion and spinal cord neurons of normal and trisomy 16 fetal mice. Developmental Brain Research 32(1): 111-122

Dorsal root ganglion (DRG) and spinal cord neurons from normal and trisomy 16 fetal mice, and animal model for human trisomy 21 (Down syndrome), were maintained in primary culture and their electrical membrane properties were compared with intracellular recording techniques. After 3-4 weeks in culture, trisome DRG neurons had a higher mean resting potential (+10%), a higher specific membrane resistance (+50%) and higher excitability (+17%), a shorter action potential (-22%), higher maximal rates of depolarization (+39%) and of two phases of repolarization (+20% and +10%) and a lower duration (-42%) of the afterhyperpolarization, than did control DRG neurons (P < 0.05). The duration of the action potential was 2 .times. greater than in control neurons, when external calcium was elevated from 1.2 to 10 mM. Differences in the electrical parameter like those observed in DRG neurons also were found in cultured spinal cord neurons. These results indicate that trisomy 16 in fetal mice alters passive and active electrical membrane properties in DRG and spinal cord neurons, and suggest that some differences are related to differences in calcium currents.

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Accession: 005349728

PMID: 2952222

DOI: 10.1016/0165-3806(87)90144-1

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