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Electrophysiological studies of dorsal column dysfunction in experimental diabetic and 2 5 hexanedione neuropathy rats






Journal of the Japan Diabetes Society 31(3): 223-230

Electrophysiological studies of dorsal column dysfunction in experimental diabetic and 2 5 hexanedione neuropathy rats

Dorsal column function in experimental diabetic (DM) rats was evaluated and compared with that in 2,5-hexanedione (2,5-HD) neuropathy rats. Hyperglycemia was induced by a single injection of streptozotocin and the experiments were performed 4 and 12 weeks after the injection. 2,5-HD was administered daily with drinking water or 8 weeks to make 2,5-HD neuropathy rats. Age-matched rats were used as controls. In DM rats, gracile surface potentials evoked by electrical stimulation of the lumbo-sacral trunk remained normal during the experimental period, whereas the N- and P-waves of the evoked potentials were supressed and the duration of the N-wave was prolonged in 2,5-HD rats. In 4-week DM rats, antidromic compound action potentials of the gracile tract were normal. In 12-week DM rats, the gracile tract conduction velocity (GTCV) was decreased, but the duration of these potentials was normal. In 2,5-HD rats, the GTCV was decreased and the duration was markedly prolonged. In spite of the of the absence of dorsal column dysfunction, maximum conduction velocities of both motor and sensory fibers in the peripheral nerve were markedly reduced in 4-week DM rats. These findings suggests that dorsal column function is more severely impaired in 2,5-HD rats than in DM rats, and that in DM rats the dorsal column is less vulnerable than peripheral nerves.


Accession: 005349772



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