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Electrophysiological studies of excitation contraction coupling during activation of alpha adrenoceptors in the vascular smooth muscles


Byulleten' Eksperimental'noi Biologii i Meditsiny 102(12): 655-657
Electrophysiological studies of excitation contraction coupling during activation of alpha adrenoceptors in the vascular smooth muscles
.alpha.1-adrenoceptor blocker.sbd.prazosin.sbd.was found to inhibit noradrenaline-induced depolarization and concentration in the smooth muscles of the portal rabbit vein, indicating tnat this reaction was due to .alpha.1-adrenoceptor activation. In the pulmonary artery both .alpha.1 and .alpha.2-adrenoceptors appear to be involved in noradrenaline excitatory action, as the effect was not completely inhibited by prazosin. The results suggest that hypotensive action of prazosin is related to the cessation of Ca2+ ion influx through .alpha.1-operated calcium channels. The decrease in Ca2+ influx through voltage-dependent calcium channels due to prazosin-evoked elimination of depolarization can also contribute to this effect.


Accession: 005349773



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