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Electrophysiological studies of nerve conductions in diabetic patients

Nagoya Medical Journal 29(2): 107-126

Electrophysiological studies of nerve conductions in diabetic patients

Electrophysiological nerve conduction studies were performed in 30 diabetic patients by testing the sensory fibers of the median, sural and posterior tibial nerves and the motor fibers of median and posterior tibial nerves. Mixed nerve conduction velocity (MNCV) was also examined in another 92 diabetic patients by the H-reflex method in the lower limb. Motor and sensory conduction velocity was measured as an indicator of myelin function and sensory amplitude as an indicator to evaluate axonal function. In diabetic patients, the sensory amplitudes were decreased significantly as compared to the small reduction of sensory conduction velocity. Diabetic duration was not related to the sensory conduction velocities. Glycemic control was more strongly related to the motor conduction than the sensory conduction. Retinopathy was not related to the sensory conduction velocities, but related to the motor conduction velocity. No objective symptoms of diabetic patients were positively correlated with the impaired conduction of sensory and motor fibers. Hemoglobin A1 levels showed a negative correlation with MNCV, indicating that diabetic neuropathy is influenced by glycemic control. Normalization of blood glucose level is an important factor to prevent diabetic neuropathy.

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Accession: 005349777

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