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Electrophysiological studies on neuronal transmission in the frogs rana esculenta photosensory pineal organ the effect of amino acids and biogenic amines


, : Electrophysiological studies on neuronal transmission in the frogs rana esculenta photosensory pineal organ the effect of amino acids and biogenic amines. Vision Research 24(12): 1727-1734

A variety of putative neurotransmitter substances and their analogues were used to characterize the synaptic connections from photoreceptors to ganglion cells in the pineal organ of the frog. The effects of all agents were tested on electrophysiologically identified luminance cells of the pineal organ. L-Aspartate and L-glutamate caused a significant increase of neuronal cell firing, the effects were dose-related, reversible and reproducible. The aspartate and glutamate agonists N-methyl-D-aspartate and kainate possess a similar ability to induce neuronal excitations in the pineal organ, N-methyl-D-aspartate being more potent than kainic acid. The excitatory action of all agents persisted if the ganglion cells were isolated from other synaptic inputs by Co2+-treatment. The excitatory action of the amino acids was antagonized by D-.alpha.-aminoadipate (D-.alpha.-AA); the order of sensitivity to antagonism by D-.alpha.-AA was: N-methyl-D-aspartate > -aspartate< L-aspartate >L-glutamate .simeq. kainate. Taurine, by far the most abundant amino acid in pineal tissues, markedly decreased the spontaneous activity in half of the neurons tested, the remaining cells being unresponsive. The indoleamine serotonin effectively depressed the maintained activity also in half of the cells tested. Acetylcholine had only small effects on pineal luminance cells. L-aspartate (and/or glutamate) might interact with postsynaptic receptors in the ganglion cell membrane and mimics the action of the natural photoreceptor transmitter.

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Meissl, H.; George, S.R., 1984: Electrophysiological studies on neuronal transmission in the frog's photosensory pineal organ. The effect of amino acids and biogenic amines. A variety of putative neurotransmitter substances and their analogues were used to characterize the synaptic connections from photoreceptors to ganglion cells in the pineal organ of the frog. The effects of all agents were tested on electrophysiol...

Owman C.; Ruedeberg C.; Ueck M., 1970: Fluorescence microscopic studies of biogenic amines in the pineal organ of rana esculenta and rana pipiens. Zeitschrift fuer Zellforschung und Mikroskopische Anatomie 111(4): 550-558

Meissl, H.; George, S.R., 1985: Effect of GABA and its antagonists, bicuculline and picrotoxin, on nerve cell discharges of the photosensory pineal organ of the frog, Rana esculenta. The effect of gamma-aminobutyric acid (GABA) and its antagonists, bicuculline and picrotoxin, was studied on pineal neurons of the frog, Rana esculenta. The drugs were applied by microiontophoresis while monitoring the spontaneous activity and lig...

Meissl H.; George S.R., 1985: Effect of gamma aminobutyric acid and its antagonists bicuculline and picrotoxin on nerve cell discharges of the photosensory pineal organ of the frog rana esculenta. The effect of GABA and its antagonists, bicuculline and picrotoxin, was studied on pineal neurons of the frog, R. esculenta. The drugs were applied by microiontophoresis while monitoring the spontaneous activity and light-evoked responses of elect...

Meissl H.; Donley C.S., 1978: Free amino acids in the pineal organ of the rainbow trout salmo gairdneri and the frog rana esculenta. General & Comparative Endocrinology 34(1): 76

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Sato, T., 1990: Histochemical demonstration of NADPH-diaphorase activity in the pineal organ of the frog (Rana esculenta), but not in the pineal organ of the rat. Using the histochemical method for the demonstration of NADPH-diaphorase activity, the pineal organ of the frog and rat was investigated in serial sections. A positive NADPH-diaphorase activity was demonstrated in pinealocytes and nerve cells in t...

Wake, K.; Ueck, M.; Oksche, A., 1974: Acetylcholinesterase-containing nerve cells in the pineal complex and subcommissural area of the frogs, Rana ridibunda and Rana esculenta. Cell and Tissue Research 154(4): 423-442

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