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Electrophysiological study in the kindling effect i. influence of the kindling effect on consciousness motor activity and gastric mucosa






Journal of the Kansai Medical University 39(3): 267-296

Electrophysiological study in the kindling effect i. influence of the kindling effect on consciousness motor activity and gastric mucosa

An electrophysiological study was made on kindled rabbits, which were prepared in the amygdaloid nucleus, hippocampus, cerebral cortex and so on, on the threshold of the arousal-like reaction and the evoked muscular discharge due to stimulation of the cerebral cortex and separatedly the stimulation of hippocampus on another kindled rabbits. The gastric lesion was also exmained. 1) In control group, one with no changes and others with some rises were observed in the threshold of arousal-like reaction and evoked muscular discharge due to 100 Hz stimulation of cerebral cortex. 2) In amygdaloid kindled group, both the threshold of the arousal-like reaction and the evoked muscular discharge due to 100 Hz stimulation of cerebral cortex declined. 3) In hippocampal kindled group, both the thresholds by 100 Hz stimulation of cerebral cortex also decreased. 4) In cortical kindled group, both the thresholds by 100 Hz stimulation of cerebral cortex decreased like in other two kindled groups. 5) In control group, certain rise on every rbbit was observed in the threshold of evoked muscular discharge due to 100 Hz stimulation of hippocampus. 6) In amygdaloid kindled group, the threshold of evoked muscular discharge due to 100 Hz stimulation of hippocampus declined. 7) In control group, gastric erosion cases showed at the rate of 20%. 8) In kindled groups, overall gastric erosion cases appeared at the rate of 68%. Namely its rate was 80% in amygdaloid kindled group and 100% in hippocampal kindled one. On the other hand, in cortical kindled one its rate was low, which was 42%. 9) Stomach ulcer was found in two cases, and one was in amygdaloid kindled rabbit and the other was in septal kindled one. Based on the above results, it can be concluded that kindling phenomena of neocortex, paleocortex and archicortex all have facilitating effects on the level of consciousness and motor activity. And the gastric findings indicate that the kindling phenomena can be applied to an experimental model of a stress disease.


Accession: 005349821



Related references

Okamoto, M., 1987: Electrophysiological study in the kindling effect ii. influence of exteroceptive stimulation on the kindling effect. The changes in consciousness and motor activity due to exteroceptive stimulation in the presence and the absence of flash stimuli were studied in the kindled rabbits. The exteroceptive stimulation consisted of the attachment of a hard contact lens...

Kudo, T.; Yagi, K.; Seino, M., 1997: Effect of motor cortical kindling on subsequent ventral hippocampal kindling and the role of the corpus callosum in the cat. The effect of bilateral motor cortical (MC) kindling on subsequent unilateral ventral hippocampal (VHIPP) kindling was studied in four cats with the corpus callosum (CC) intact and five cats with the CC bisected, compared with nine cats with unila...

Dennison, Z.; Teskey, G.C.; Cain, D.P., 1995: Persistence of kindling: effect of partial kindling, retention interval, kindling site, and stimulation parameters. The kindling effect is generally thought to be highly persistent and possibly permanent, but little direct evidence is available to support this idea. Retention of amygdala kindling was examined after a 12-wk interval in groups of rats that had be...

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Loescher, W.; Hoerstermann, D.; Hoenack, D.; Rundfeldt, C.; Wahnschaffe, U., 1993: Transmitter amino acid levels in rat brain regions after amygdala-kindling or chronic electrode implantation without kindling: Evidence for a pro-kindling effect of prolonged electrode implantation. Kindling is a chronic model of epilepsy characterized by a progressive increase in response to the same regularly applied stimulus. The biological basis of the kindling phenomenon requires to be determined, but several studies indicate that altera...

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Racine, R.J.; Steingart, M.; Mcintyre, D.C., 1999: Development of kindling-prone and kindling-resistant rats: Selective breeding and electrophysiological studies. Because of the growing need for an animal model of complex partial seizures based on a genetic predisposition, we combined the kindling model of epilepsy with selective-breeding procedures to develop two new lines (or strains) of rats that are kin...

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