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Electrophysiological study in the kindling effect i. influence of the kindling effect on consciousness motor activity and gastric mucosa






Journal of the Kansai Medical University 39(3): 267-296

Electrophysiological study in the kindling effect i. influence of the kindling effect on consciousness motor activity and gastric mucosa

An electrophysiological study was made on kindled rabbits, which were prepared in the amygdaloid nucleus, hippocampus, cerebral cortex and so on, on the threshold of the arousal-like reaction and the evoked muscular discharge due to stimulation of the cerebral cortex and separatedly the stimulation of hippocampus on another kindled rabbits. The gastric lesion was also exmained. 1) In control group, one with no changes and others with some rises were observed in the threshold of arousal-like reaction and evoked muscular discharge due to 100 Hz stimulation of cerebral cortex. 2) In amygdaloid kindled group, both the threshold of the arousal-like reaction and the evoked muscular discharge due to 100 Hz stimulation of cerebral cortex declined. 3) In hippocampal kindled group, both the thresholds by 100 Hz stimulation of cerebral cortex also decreased. 4) In cortical kindled group, both the thresholds by 100 Hz stimulation of cerebral cortex decreased like in other two kindled groups. 5) In control group, certain rise on every rbbit was observed in the threshold of evoked muscular discharge due to 100 Hz stimulation of hippocampus. 6) In amygdaloid kindled group, the threshold of evoked muscular discharge due to 100 Hz stimulation of hippocampus declined. 7) In control group, gastric erosion cases showed at the rate of 20%. 8) In kindled groups, overall gastric erosion cases appeared at the rate of 68%. Namely its rate was 80% in amygdaloid kindled group and 100% in hippocampal kindled one. On the other hand, in cortical kindled one its rate was low, which was 42%. 9) Stomach ulcer was found in two cases, and one was in amygdaloid kindled rabbit and the other was in septal kindled one. Based on the above results, it can be concluded that kindling phenomena of neocortex, paleocortex and archicortex all have facilitating effects on the level of consciousness and motor activity. And the gastric findings indicate that the kindling phenomena can be applied to an experimental model of a stress disease.

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Accession: 005349821



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