EurekaMag.com logo
+ Site Statistics
References:
48,253,228
Abstracts:
22,798,842
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Electrophysiological study in the kindling effect iii. effects of trh analog dn 1417 on electrical phenomena in the kindled rabbit


, : Electrophysiological study in the kindling effect iii. effects of trh analog dn 1417 on electrical phenomena in the kindled rabbit. Journal of the Kansai Medical University 39(3): 310-319

With amygdaloid kindled rabbits, effects of DN-1417 (TRH analog) were examined on electrical phenomena; (a) the thresholds of the arousal-like reaction and of the evoked muscular discharge due to 100 Hz stimulation of the cerebral cortex, and (b) the afterdischarge duration. For the purpose of comparison, the effect of Pentobarbital was examined on another group of amygdaloid kindled rabbits. DN-1417 was intravenously administered at three different doses (0.2, 2.0 and 20.0mg/kg). Pentobarbital was intravenously administered at three different doses (0.5, 3.0 and 5.0mg/kg). (1) DN-1417 elevated the thresholds of the arousal-like reaction and of the evoked muscular discharge at the dose of 2.0mg/kg i.v. and lasted for 10 to 30 min. But DN-1417 had no effect at other doses. (2) Pentobarbital elevated the thresholds of the arousal-like reaction and of the evoked muscular discharge. This drug had a dose-dependent effect. (3) DN-1417 induced afterdischarge to disappear or reduce at the dose of 2.0 mg/kg i.v. for 10 to 30 min. But this drug had no effect at other doses. (4) Pentobarbital induced afterdischarge to disappear or reduce. The effect was dose-dependent. These findings show that DN-1417 has a dose-independent anticonvulsant effect while Barbiturate has a dose-dependent effect.

(PDF 0-2 workdays service)

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 005349823

PDF Full Text: Submit


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Munch, S., 1965: The development of Cuban agriculture. Part I. This first of a series of papers on the agricultural development of Cuba is mainly a review of literature in Spanish dealing with the agricultural structure before the revolution. It discusses among other topics the land tenure pattern, land use a...

Landau, R., 1991: Mirogrex terraesanctae (Cyprinidae) of Lake Kinneret: biomass changes in relation to inflow; growth rate in relation to fish/zooplankton interaction. Catch analyses indicate increases in Mirogrex standing stock (exploited phase) from < 2000 tonnes in the early 1950's to > 12 000 tonnes in the mid-1980's and a declining abundance after 1986. Broad strength is related to c...

Perez, Mayte; Valdes, Israel; Pierrat, Ricardo; Garcia, Cristina; Gonzalez, Marcos; De-La-Torre, Daisy; Del-Rosario-Aleman, Maria; Valdes, Rodolfo, 1997: Production of monoclonal antibodies CB IFN 2.4 in the hollow fiber bioreactors ACUSYST-R and SACCEL. Monoclonal antibodies (MAbs) are produced in mice by the intraperitoneal injection of the MAb-producing hybridoma cells. The laws for animal protection and the regulations required for the production of MAbs for human use are more and more strict...

Haddad, Bassam; Kayem, Gilles; Deis, Stephanie; Sibai, Baha, M., 2007: Are perinatal and maternal outcomes different during expectant management of severe preeclampsia in the presence of intrauterine growth restriction?. American Journal of Obstetrics and Gynecology 196(3): 237-239

Yue-Min; Qiu-De-Xin; Chen-Huan-Chun; Jiang-Zeng-Hai, 2004: Expression of the combined orf7 and orf5 genes of porcine reproductive and respiratory syndrome virus in E.coli. According to the nucleotide sequence of Porcine reproductive and respiratory syndrome virus (PRRSV), two pairs of primers were designed and used to amplified the orf7 and orf5 genes by RT-PCR, respectively. By using the EcoRI.SpeI and Hind III sit...

Boukthir, S.; Fetni, I.; Mrad, S. Mazigh; Mongalgi, M. A.; Debbabi, A.; Barsaoui, S., 2004: Corticotherapie a forte dose dans le traitement des oesophagites caustiques severes chez l'enfant. Esophageal burns are frequent in some countries. Esophageal stricture is a severe complication after caustic ingestion. Its frequency is estimated to 5% and reaches 47% in severe esophagitis. Aim of the study. - To study the influence of managemen...

Turner, Susan; Miller, Randall F., 2008: Protodus jexi Woodward, 1892 Chondrichthyes, from the Lower Devonian Campbellton Formation, New Brunswick, Canada. Acta Geologica Polonica 58.2: 133-145

Vinogradova E.I.; Fonina L.A.; Ryabova I.D.; Ivanov V.T., 1974: Synthesis of new analogs of valinomycin part 2. Khimiya Prirodnykh Soedinenii (3): 278-286

Fomenta, A. Y., 1939: Attempts to Infect Rabbits with the Virus of Equine Infectious Anaemia. After injection of washed red blood corpuscles of infected horses into rabbits, a condition similar to E.I.A. is said to have developed. Attempts to infect horses with material from these infected rabbits were unsuccessful.

Smith Thomas E., 1987: North Star gold investigations. Proceedings of the Annual Conference on Alaskan Placer Mining 9: 183-188