Electrophysiological study in the kindling effect iii. effects of trh analog dn 1417 on electrical phenomena in the kindled rabbit

Okamoto, M.

With amygdaloid kindled rabbits, effects of DN-1417 (TRH analog) were examined on electrical phenomena; (a) the thresholds of the arousal-like reaction and of the evoked muscular discharge due to 100 Hz stimulation of the cerebral cortex, and (b) the afterdischarge duration. For the purpose of comparison, the effect of Pentobarbital was examined on another group of amygdaloid kindled rabbits. DN-1417 was intravenously administered at three different doses (0.2, 2.0 and 20.0mg/kg). Pentobarbital was intravenously administered at three different doses (0.5, 3.0 and 5.0mg/kg). (1) DN-1417 elevated the thresholds of the arousal-like reaction and of the evoked muscular discharge at the dose of 2.0mg/kg i.v. and lasted for 10 to 30 min. But DN-1417 had no effect at other doses. (2) Pentobarbital elevated the thresholds of the arousal-like reaction and of the evoked muscular discharge. This drug had a dose-dependent effect. (3) DN-1417 induced afterdischarge to disappear or reduce at the dose of 2.0 mg/kg i.v. for 10 to 30 min. But this drug had no effect at other doses. (4) Pentobarbital induced afterdischarge to disappear or reduce. The effect was dose-dependent. These findings show that DN-1417 has a dose-independent anticonvulsant effect while Barbiturate has a dose-dependent effect.