+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Electrophysiological study of cardiovascular neurons in the rostral ventrolateral medulla in rats

Circulation Research 56(3): 359-369
Electrophysiological study of cardiovascular neurons in the rostral ventrolateral medulla in rats
In urethane-anesthetized rats, electrophysiological recordings of spontaneously active neurons in the vasopressor area of the rostral ventrolateral medulla were analyzed for participation in cardiovascular regulation. A total of 138 units were found which were inhibited by transient increases in mean arterial pressure elicited by intravenous injection of norepinephrine, aortic occlusion, or electrical stimulation of the hypothalamus, with 100% inhibition occurring at 148 mm Hg. Histograms of postsystolic activity showed that these units had pulse-synchronous rhythms which grew more prominent as arterial pressure increased. Furthermore, electrical stimulation of the superior laryngeal nerve, which elicited a vasodepressor response, strongly inhibited these units. Thus, these neurons were termed negatively correlated cardiovascular units. At least half of these cells project to or through the thoracic spinal cord. In addition, arterial pressure sensitivity is conveyed through carotid sinus and aortic arch afferents. Approximately half of the cardiovascular units are also excited by hypothalamic stimulation. Finally, analysis of neighboring cells showed that it is possible to distinguish between cardiovascular and respiratory units. These data are consistent with the concept of a medullary center which supports tonic sympathetic vasomotor tone and which mediates baroreceptor reflexes, as well as vascular responses of the defense reaction.

Accession: 005349827

PMID: 3971510

DOI: 10.1161/01.res.56.3.359

Related references

Electrophysiological correlates of the cardiovascular regulatory neurons of the rostral ventrolateral medulla. Society for Neuroscience Abstracts 15(2): 1182, 1989

Electrophysiological identification of depressor neurons in the caudal ventrolateral medulla with projections to rostral ventrolateral medulla in the rabbit. Society for Neuroscience Abstracts 18(1-2): 1269, 1992

Electrophysiological properties of neurons in the rostral ventrolateral medulla of normotensive and spontaneously hypertensive rats. Brain Research 549(1): 118-126, 1991

Electrophysiological properties of rostral ventrolateral medulla presympathetic neurons modulated by the respiratory network in rats. Journal of Neuroscience 33(49): 19223-19237, 2014

Supramedullary inputs to cardiovascular neurons of rostral ventrolateral medulla in rats. American Journal of Physiology 265(1 Pt 2): R111-R116, 1993

Rapid effects of corticosterone on cardiovascular neurons in the rostral ventrolateral medulla of rats. Brain Research 815(1): 51-59, Jan 2, 1999

Electrophysiological properties of pre-sympathetic neurons in the rostral ventrolateral medulla in the rat An intracellular study in vivo. Society for Neuroscience Abstracts 20(1-2): 843, 1994

Effects of chronic captopril treatment on the electrical-microstimulation-induced blood pressure changes and electrophysiological properties of cardiovascular neurons in the rostral ventrolateral medulla of the spontaneously hypertensive rat. Biological Signals 2(2): 106-116, 1993

Intracellular study of different cardiovascular non catecholaminergic neurons in the c1 area in the rostral ventrolateral medulla. European Journal of Pharmacology 183(2): 453, 1990

Characterization of different cardiovascular neurons in the rostral ventrolateral medulla an in vivo intracellular study. FASEB Journal 4(4): A1192, 1990