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Electrophysiological study on animal model of depression single unit activity of locus coeruleus neurons in rats exposed to long term severe stress


Mie Medical Journal 37(1): 1-16
Electrophysiological study on animal model of depression single unit activity of locus coeruleus neurons in rats exposed to long term severe stress
The spontaneous and evoked activity of locus coeruleus neurons was studied by extracellular recording in the following three groups of rats exposed to forced running stress: 3-day stress rats, which were stressed for three days, depression-model rats, which remained inactive after long-term forced running stress, and recovery rats, which gradually recovered from the inactive state after the long-term stress. The spontaneous firing rates tended to decrease in 3-day stress rats. In depression-model rats, the rate significantly decreased in comparison with that in control and recovery rats. The rate in recovery rats was the same as in control rats. The number of evoked spikes in response to foot-shock also significantly decreased in depression-model rats. The inhibitory effect of imipramine on the spontaneous firing rate was more marked in depression-model rats. These findings suggest that unit activity of locus coeruleus neurons is decreased in depression-model rats.


Accession: 005349864



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