EurekaMag.com logo
+ Site Statistics
References:
47,893,527
Abstracts:
28,296,643
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Electrophysiological study on cone rod dystrophy of bull's eye macular lesion type


, : Electrophysiological study on cone rod dystrophy of bull's eye macular lesion type. Nihon University Journal of Medicine 28(3): 175-188

Nine cases of cone-rod dystrophy of bull's eye macular lesion type were examined electrophysiologically. 7 eyes of 7 normal cases were studied as a control by the same electrophysiological techniques. 1) Widespread cone-dysfunction could be detected from abnormalities of the photopic b wave, rapid off decay and 30 Hz flicker ERG. 2) The degree of cone-dysfunction which was evaluated from the abnormalities of the photopic b wave and 30 Hz flicker ERG was found not to correlate with the extent of the pathologic lesion as demonstrated by fluorescein angiography and ophthalmoscopy. 3) The results of color vision tests in 5 cases were compared with their spectral response curves, which were obtained from the amplitude of the rapid off decay of ERG stimulated by monochromatic light of various wavelengths. The total error scores of the color vision tests were found to correlate with the amplitude of the monochromatic ERG. 4) Even in cases which showed ophthalmoscopic abnormalities only in the macular area, an abnormal scotopic b wave was observed. These results indicate that rod dysfunction precedes discernible ophthalmoscopic abnormalities.


Accession: 005349865

Submit PDF Full Text: Here


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Related references

Michaelides, M.; Gaillard, M-Claire.; Escher, P.; Tiab, L.; Bedell, M.; Borruat, Fçois-Xavier.; Barthelmes, D.; Carmona, R.; Zhang, K.; White, E.; McClements, M.; Robson, A.G.; Holder, G.E.; Bradshaw, K.; Hunt, D.M.; Webster, A.R.; Moore, A.T.; Schorderet, D.F.; Munier, F.L., 2010: The PROM1 mutation p.R373C causes an autosomal dominant bull's eye maculopathy associated with rod, rod-cone, and macular dystrophy. To characterize in detail the phenotype of five unrelated families with autosomal dominant bull's eye maculopathy (BEM) due to the R373C mutation in the PROM1 gene. Forty-one individuals of five families of Caribbean (family A), British (fami...

Scholl, H.P.; Kremers, J.; Wissinger, B., 2001: Macular dystrophy with protan genotype and phenotype studied with cone type specific ERGs. To determine the L- and M-cone driven ERG responses in a male patient with macular dystrophy and a protan phenotype. We measured large field ERG thresholds to stimuli which modulated exclusively the L- or the M-cones or the two in various combinat...

Ladewig, M.; Kraus, H.; Foerster, M.H.; Kellner, U., 2003: Cone dysfunction in patients with late-onset cone dystrophy and age-related macular degeneration. Objectives: To determine the clinical and functional findings in patients with late-onset cone dystrophy (LOCD) (after the age of 50 years), which is rare, and to compare them with those of patients with age-related macular degeneration (AMD). Met...

Kamenarova, K.; Corton, M.; García-Sandoval, B.; Fernández-San Jose, P.; Panchev, V.; Avila-Fernández, A.; López-Molina, M.Isabel.; Chakarova, C.; Ayuso, C.; Bhattacharya, S.S., 2014: Novel GUCA1A mutations suggesting possible mechanisms of pathogenesis in cone, cone-rod, and macular dystrophy patients. Here, we report two novel GUCA1A (the gene for guanylate cyclase activating protein 1) mutations identified in unrelated Spanish families affected by autosomal dominant retinal degeneration (adRD) with cone and rod involvement. All patients from a...

Langwińska-Wośko, E.; Szulborski, K.; Zaleska-Żmijewska, A.; Szaflik, J., 2015: Electrophysiological testing as a method of cone-rod and cone dystrophy diagnoses and prediction of disease progression. To determine the characteristics of patients with cone (CD) and cone-rod dystrophies (CRD) and to evaluate the changes in flash electroretinograms in both groups. The retrospective study involved 48 patients-34 with CRD and 14 with CD. The patient...

Tojo, N.; Nakamura, T.; Ozaki, H.; Oka, M.; Oiwake, T.; Hayashi, A., 2013: Analysis of macular cone photoreceptors in a case of occult macular dystrophy. To investigate changes in cone photoreceptors with adaptive optics (AO) fundus imaging and spectral domain optical coherence tomography (SD-OCT) in a case of occult macular dystrophy (OMD). Both eyes of a 42-year-old woman diagnosed with OMD were...

Galli-Resta, L.; Piccardi, M.; Ziccardi, L.; Fadda, A.; Minnella, A.; Marangoni, D.; Placidi, G.; Resta, G.; Falsini, B., 2013: Early detection of central visual function decline in cone-rod dystrophy by the use of macular focal cone electroretinogram. To evaluate macular focal cone ERG (fERG) as a tool for reliable and early detection of central retinal function decay in cone-rod dystrophy (CRD). A retrospective study of the time course of fERG amplitude and its relation to visual acuity altera...

Michaelides, M.; Wilkie, S.E.; Jenkins, S.; Holder, G.E.; Hunt, D.M.; Moore, A.T.; Webster, A.R., 2005: Mutation in the gene GUCA1A, encoding guanylate cyclase-activating protein 1, causes cone, cone-rod, and macular dystrophy. Purpose: To determine the underlying molecular genetic basis of a retinal dystrophy identified in a 4-generation family and to examine the phenotype and the degree of intrafamilial variability.Design: Prospective case series.Participants: Six affe...

Miyake, Y.; Horiguchi, M.; Kondo, M.; Terasaki, H.; Nomura, R., 1998: Depolarizing pattern of macular cone ERG in human macular dystrophy. IOVS 39(4): S723, March 15

Francois J.; Victoria Troncoso V., 1975: Histo pathogenic study of the macular dystrophy of the cornea fehrs dystrophy or groenouws type ii. Ophthalmic Research 7(4): 261-269