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Endorphin induced hyper thermia characterization of the exogenously and endogenously induced effects



Endorphin induced hyper thermia characterization of the exogenously and endogenously induced effects



Naunyn-Schmiedeberg's Archives of Pharmacology 309(2): 137-144



Endorphins, like opiates, increase temperatures in rats at very low doses and decrease temperature at high doses. Both effects on temperature seem to be mediated through opiate receptors, as they are antagonized by naloxone and diminished in morphine-tolerant and -dependent animals. Like opiate-induced hyperthermia, both the pharmacological and the supposedly physiological increase in temperature induced by endorphins were strongly diminished in restrained animals. Hyperthermia induced by pyrogens was not antagonized by naloxone or by restraining the animals. Maintenance of normal body temperature in animals exposed to acute cold was not disturbed by administration of naloxone. Physiologically induced naloxone-antagonizable hyperthermia may be a sensitive measure for endorphin release. Endorphins, although potent hyperthermic modulators, do not seem to be directly involved in the central regulation of temperature. The physiologically induced increase in temperature by endorphins seems not to be related to the physiological requirements for the support of thermostability.

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Accession: 005359018

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PMID: 522899


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