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Endorphin induced increase in striatal dopamine turnover



Endorphin induced increase in striatal dopamine turnover



Life Sciences 23(9): 961-970



Human .beta.-endorphin administered intracisternally in a dose of 15 .mu.g/rat increased striatal concentrations of the dopamine metabolites, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) as well as producing catalepsy. These effects were inhibited by naloxone. Pargyline-induced decreases in striatal DOPAC and HVA were greater in endorphin-treated than in saline-treated animals, supporting the concept that .beta.-endorphin increases striatal dopamine turnover. .beta.-endorphin increased the rate of decline in striatal dopamine concentration following synthesis inhibition with .alpha.-methyltyrosine, further suggesting that endorphin increases striatal dopamine turnover. .beta.-endorphin and probenecid interacted competitively to decrease the effects of each other to increase striatal HVA. Naloxone prevented the effect of endorphin to decrease the HVA response to probenecid. Probenecid cannot be used to assess the effects of endorphin on striatal dopamine turnover. If .beta.-endorphin acts presynaptically to decrease dopamine release in striatum, the increases in striatal DOPAC and HVA probably represent a compensatory attempt to increase dopamine synthesis. Although turnover of dopamine to its metabolites is increased, dopamine release may be suppressed by .beta.-endorphin.

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Accession: 005359019

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