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Endorphin-regulated protein phosphorylation in brain membranes



Endorphin-regulated protein phosphorylation in brain membranes



Life Sciences 26(21): 1765-1772



It was determined whether opioid peptides exert direct effects on the phosphorylation of specific proteins in membranes from rat neostriatum. Low concentrations of .beta.-endorphin (0.1-10 nM) inhibit the phosphorylation of specific proteins designated F and H (MW 47,000 and 10-20,000, respectively). In addition, .beta.-endorphin produced an overall stimulation of phosphate incorporation into other membrane proteins, the phosphorylation of which is dependent on Ca ions. The stimulatory effects were blocked by naloxone, but the inhibitory effects were not. The regulation of membrane protein phosphorylation by endorphins may constitute a biochemical mechanism mediating some of the physiological effects of these peptides on neuronal function.

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Accession: 005359027

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PMID: 7392812



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