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Endorphins in cerebro spinal fluid of chronic pain patients in relation to augmenting reducing response in visual averaged evoked response



Endorphins in cerebro spinal fluid of chronic pain patients in relation to augmenting reducing response in visual averaged evoked response



Neuropsychobiology 5(6): 322-326



In 45 consecutive patients with chronic pain, visual averaged evoked responses (VAER) and the levels of fraction 1 endorphins in CSF were investigated. Patients with an augmenter response in VAER, i.e., the maximum amplitude increases when stimulus intensity is increased, had significantly lower levels of fraction 1 endorphins than patients with a reducer response, i.e., the maximum amplitude in VAER decreases when stimulus intensity is increased. The endorphins function as endogenous antinociceptive factors.

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Accession: 005359053

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