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Endorphins in schizophrenia

Endorphins in schizophrenia

Neuropharmacology 20(12b): 1271-1277

Endorphins were implicated in schizophrenic psychoses. There different lines of research were followed: endorphin excess, evaluated by analyses of endorphin levels in body fluids and by treating schizophrenic patients with opiate antagonists or hemodialysis; endorphin deficiency leading to administration of the opiate peptides .beta.-endorphin and FK33-824 [(D-Ala2, MePhe4, Met(o)5-ol) enkephalin] to schizophrenic patients; a disbalance in .beta.-endorphin fragments, particularly a reduced bioavailability of neuroleptic-like .gamma.-type endorphins, resulting in clinical trials in which the antipsychotic effect of (des-Tyr1)-.gamma.-endorphin and (des-enkephalin)-.gamma.-endorphin was demonstrated in schizophrenic patients. The results of the clinical studies are summarized and the postulate which assumes a disbalance between .alpha., .beta. and .gamma.-type endorphins as an etiological factor in the psychopathology of schizophrenia is discussed in relation to the dopamine hypothesis of this mental disorder.

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Accession: 005359059

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PMID: 6172743

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