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Endorphins: naloxone fails to alter experimental pain or mood in humans

Endorphins: naloxone fails to alter experimental pain or mood in humans

Science 199(4333): 1093-1095

In 30 human subjects, experimental pain was produced by either ischemia or cold-water immersion. In a double-blind procedure, intravenous doses of up to 10 milligrams of naloxone hydrochloride in saline were indistinguishable from similarly administered saline alone. There were no effects on subjective pain ratings, finger plethysmograph recordings, or responses to mood-state questionnaires. These laboratory procedures do not activate any functionally significant pain-attenuating or mood-altering effect of endorphins.

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Accession: 005359066

Download citation: RISBibTeXText

PMID: 343250

DOI: 10.1126/science.343250

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