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Endoscopic and histologic correlations of the duodenal bulb the spectrum of duodenitis



Endoscopic and histologic correlations of the duodenal bulb the spectrum of duodenitis



Archives of Pathology & Laboratory Medicine 103(4): 169-172



The correlation between the endoscopic and histologic findings in the normal duodenal bulb and in duodenitis was investigated in 50 patients by gastrointestinal (Gl) panendoscopy, along with an assessment of the clinical settings in which endoscopic duodenitis was present. Of 36 endoscopically normal duodenal bulbs, 35 (97%) were histologically normal. Of 39 histoloigcally normal bulbs, 35 (90%) were endoscopically judged normal. Of 11 (91%) histologically abnormal duodenal bulbs 10 had endoscopic evidence of duodenitis, while histologic evidence of duodenitis was found in only 70% of duodenal bulbs with endoscopic evidence of duodenitis. The clinical spectrum accompanying endoscopy-proved duodenitis included peptic ulcer disease, upper Gl tract hemorrhage associated with alcohol and salicylate ingestion, dyspeptic symptoms in the absence of an active duodenal ulcer crater and nonspecific association with a number of upper Gl tract disorders. An endoscopically normal duodenal bulb will also have normal histologic features. Normal and abnormal histologic findings in the duodenal bulb have a high degree of correlation with the endoscopic interpretation (r = 0.64, P < .001). An expanding clinical spectrum is associated with the entity of endoscopy-proved duodenitis.

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Accession: 005359091

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