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Endoscopic and pathologic studies on the development courses of rat colonic carcinoma induced by intrarectal n methyl n nitrosourea administration



Endoscopic and pathologic studies on the development courses of rat colonic carcinoma induced by intrarectal n methyl n nitrosourea administration



Gastroenterological Endoscopy 26(7): 1009-1027



To elucidate natural history of the development of human colonic carcinoma, endoscopic and pathologic studies were performed on the colonic tumors induced by intrarectal administration of N-methyl-N-nitrosourea to the experimental rats. Of the tumors induced in this experiment, there were 160 small or flat elevation type, (33.7%), 189 sessile polypoid types (39.9%), 71 pedunculated types (15.0%), 44 central depression types (9.3%) and 10 unusual type (2.1%). Gross appearance of most of those tumors was similar to that of early colonic carcinoma in human. Incidence of the tumor-bearing rats was not different between male and female. However, ratio of number of tumor per 1 rat of male and female was .apprx. 2:1. Histologically, 431 colonic neoplasmas consisted of 32 adenomas (7.4%), 327 polypoid carcinomas (75.9%) and 72 carcinomas coexisted with adenomas (16.7%). Seven out of 72 carcinomas coexisted with adenomas resembled so-called carcinoma in adenoma in human. Both size of the tumor and grade of the carcinomatous invasion were not related to interval since occurrence of the tumor. Pedunculated type of the colonic carcinoma transformed to sessile polypoid type of the colonic carcinomatous invasion into the stalk. As the morphogenesis of the colonic ulcerative advanced carcinoma, 3 different developmental courses were confirmed; ulceration due to carcinomatous invasion into the stalk of the pedunculated type of carcinoma, ulcer formation of the sessile polypoid type of carcinoma and development of the tiny ulcerative type of carcinoma since initial stage. Although the incidence of the tiny ulcerative type of carcinoma was low, grade of the malignancy was high. The tiny ulcerative type of carcinoma might play an important role in the development of ulcerative advanced carcinoma. The diffuse infiltrative and constrictive type of colonic carcinoma developed as the non-polypoid type since the initial stage.

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