EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Endoscopic assessment of the effect of the pre operative combined therapy in the esophageal cancer



Endoscopic assessment of the effect of the pre operative combined therapy in the esophageal cancer



Gastroenterological Endoscopy 27(3): 303-315



The effect of pre-operative combined therapy with radiation as its main component was evaluated by surgical specimen in 173 [human] cases of esophageal cancer from 1969-1982. The main points of the present investigation were: establishment of criteria to judge the effects of combined therapy; correlation between the histological features and the criteria established; and evaluation of the predictive effects of the combined therapy through endoscopical findings. According to the judgment criteria, the effect was classified in 4 types: complete response, partial response, minor improvement and no improvement. A significant correlation was found between the histological features and the reestablished criteria. Taking into account the changes of the endoscopic findings due to combined therapy, the most appropriate time to judge its effects was between 2 or 3 days before the operation. In order to estimate the predictable effect of the pre-operative combined therapy the 3 following items related to the main tumor were considered: the configuration of the elevation; the exposure of the cancerous region after using lugol solution; and the configuration of the oral side of the tumor. The 1st 2 items were subdivided in 4 types, and the 3rd one in 3 types. For each case, the sum of the above mentioned items was used as the index of evaluation of the effect. According to the pre-operative combined therapy which was used, the indices found for effects EF1 [endoscopic effect] EF2 and EF3 were: -0.180 .+-. 0.303, -0.010 .+-. 0.291 and 0.183 .+-. 0.142, respectively. A good correlation was found between this index of evaluation and the recent clinical cases.

(PDF emailed within 1 workday: $29.90)

Accession: 005359115

Download citation: RISBibTeXText



Related references

Endoscopic ultrasonography for assessment of the response to combined radiation therapy and chemotherapy in patients with esophageal cancer. Endoscopy 29(1): 4-9, 1997

Study on effect of pre-operative combined therapy against esophageal cancer--with special reference to histologic and radiologic criteria for the effect of radiation and chemotherapy. Nihon Gan Chiryo Gakkai Shi 20(1): 1-8, 1985

Study on the effect of pre operative combined therapy against esophageal cancer special reference to histologic and radiologic criteria for the effect of radiation and chemotherapy. Journal of Japan Society for Cancer Therapy 20(1): 1-8, 1985

Outcomes of Surgical Resection of T1bN0 Esophageal Cancer and Assessment of Endoscopic Mucosal Resection for Identifying Low-Risk Cancers Appropriate for Endoscopic Therapy. Annals of Surgical Oncology 23(8): 2673-2678, 2016

Esophageal cancer: CT, endoscopic US, and FDG PET for assessment of response to neoadjuvant therapy--systematic review. Radiology 236(3): 841-851, 2005

Early percutaneous endoscopic gastrostomy in combined chemo and radiation therapy for esophageal cancer is safe and effective. Gastroenterology 106(4 SUPPL ): A595, 1994

Effect of local therapy for the treatment of superficial esophageal cancer in non-operative candidates. Diseases of the Esophagus 21(8): 673-678, 2008

Symposium 2 cancer treatment by laser in the tracheo esophageal region d. endoscopic photodynamic therapy for esophageal cancer. Journal of the Japan Broncho Esophagological Society 40(2): 118-121, 1989

Combined pre operative and post operative adjuvant radio therapy for bladder cancer results of radiation therapy oncology group jefferson study. Cancer 47(12): 2840-2843, 1981

Assessment of response to neoadjuvant therapy in esophageal cancer: an updated systematic review of diagnostic accuracy of endoscopic ultrasonography and fluorodeoxyglucose positron emission tomography. Diseases of the Esophagus 23(3): 216-231, 2010

Pre-operative chemoradiation followed by post-operative adjuvant therapy with tetrathiomolybdate, a novel copper chelator, for patients with resectable esophageal cancer. Investigational New Drugs 31(2): 435-442, 2013

Combined roentgen-radium therapy of esophageal cancer significance of mucosal diagnosis of esophageal cancer for radiotherapeutical procedure. Strahlentherapie 81(3): 439-458, 1950

Endoscopic therapy of neoplasia related to Barrett's esophagus and endoscopic palliation of esophageal cancer. Cancer Control 20(2): 117-129, 2013

Double endoscopic technique for operative dilation of esophageal strictures resistant to conventional therapy. Journal of the Louisiana State Medical Society 159(3): 159-63, 165, 2007