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Endoscopic local injection of an anticancer agent into experimental canine stomach cancer



Endoscopic local injection of an anticancer agent into experimental canine stomach cancer



Kitakanto Medical Journal 35(1): 89-97



The emulsionized methyl-CCNU [1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea] (Me-CCNNU-E) was injected endoscopically into normal canine stomachs. The emulsion was detected in the submucosal layer of the stomach wall and regional lymph nodes histologically by Oil-red-O stain. Using a Me-CCNU concentration higher than 20 mg/ml, ulceration was caused in the gastric mucosa where the emulsion was injected. But when the concentration of Me-CCNU was lower than 10 mg/ml, no lesion was found. Stomach cancers were induced in 2 Beagle dogs experimentally by N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG), and Me-CCNU-E was injected directly into the tumors endoscopically. One dog had advanced stomach cancer which was classified into Borrmann type III. Me-CCNU (10 mg/ml) was injected into the tumor 9 times within 13 wk in a total dose of Me-CCNU 130 mg. At 17 wk after the initial injection, the dog was sacrificed and examined histologically. The cancer was not reduced, but degenerative findings were observed histologically in the tumor where the emulsion was injected. Regional lymph node metastasis was not found. In the other dog, a IIa + IIc shaped advanced cancer and 2 IIc shaped early cancers were induced by ENNG. A total dose of 120 mg of Me-CCNU-E(20 mg/ml) was injected into those tumors. At 12 wk after the treatment, this dog died of a perforation of the stomach. On histological examination, cancer nests remained, however, most of the tumors distinctly vanished. The endoscopic injection of anticancer agents for stomach cancer is a useful method for the treatment of stomach cancer in the cases of elderly patients and poor risk patients. The treatment of anticancer agents with emulsion was more effective in curing not only the cancer but the lymph node metastasis.

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Accession: 005359359

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