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Endoscopic local injection therapy for gastric cancer



Endoscopic local injection therapy for gastric cancer



Stomach & Intestine (Tokyo) 19(8): 895-902



Since 1965, endoscopic local injection therapy with bleomycin was performed in gastric cancer. There were 27 cases of early gastric cancer treated with this method. All patients were unable to undertake operations for some reason 2 ml of bleomycin (3 mg/ml) in sterile distilled water was injected directly into the tumor. One wk after the 2nd injection, massive necrotized tissues were removed by endoscopic forceps. Repeated bleomycin injection and removal of necrotized masses were performed weekly until the tumor could not be recognized. There was no relapse for 16 yr at the longest in a patient with early gastric cancer of IIa type. There are other endoscopic local injection therapy using mitomycin, OK-432 (picibanil), ethanol, etc. Mechanism of OK-432 suggested that macrophage appeared. With the use of mitomycin and ethanol, it was difficult to control the ulceration to tumor or normal tissue. Protruded-type of early gastric cancer is suitable for endoscopic local injection therapy. It was not effective to metastatic lymph nodes, therefore, fat emulsion of anticancer agents were devised. If surgical therapy is not applicable due to high risks, endoscopic local injection therapy is valuable for gastric cancer.

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Accession: 005359363

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