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Endoscopic measurement of esophageal transmucosal potential difference in reflux esophagitis

Endoscopic measurement of esophageal transmucosal potential difference in reflux esophagitis

Gut 25(10): 1103-1106

Esophageal transmucosal potential difference (PD) was measured in 76 patients during endoscopy. Patients (12) with no symptoms of gastro-esophageal reflux, and normal esophageal appearance on endoscopy and mucosal biopsy had a PD of -18.3 .+-. 3.8 mV (mean .+-. SD). Patients (33) had reflux symptoms but the esophagus appeared normal at endoscopy. Of these patients, 18 had reflux change on esophageal suction biopsies and the PD in the same region of the esophagus in this group was -18.1 .+-. 7.5 mV. In 15 of the patients, mucosal biopsies were normal and the PD in this group was -18.8 .+-. 9.9 mV. Patients (31) had erosive esophagitis and PD values in this group were markedly reduced. Of these patients, 27 had PD values < -10 mV. PD measured by this technique is abnormal in erosive esophagitis but is of no value in the diagnosis of mild mucosal damage in patients with reflux symptoms when endoscopic findings are normal.

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Accession: 005359378

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PMID: 6479686

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