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Endoscopic neodymium yttrium aluminum garnet laser therapy for palliative treatment of esophageal and cardiac carcinoma preliminary noncontrolled study



Endoscopic neodymium yttrium aluminum garnet laser therapy for palliative treatment of esophageal and cardiac carcinoma preliminary noncontrolled study



Gastroenterologie Clinique et Biologique 8(6-7): 545-550



An attempt was made to report results of endoscopic YAG [yttrium aluminum gernet] laser therapy in palliative treatment of esophageal and cardiac carcinoma. Twenty-eight patients were treated: 9 with adenocarcinoma and 19 with squamous cell carcinoma. Among these patients, 9 had complete aphagia; radiotherapy was contraindicated in 17; in the remaining 2 patients the aim of laser therapy was to achieve sufficient luminal enlargement to allow the endoscopic insertion of a prosthesis. Dysphagia improved in 24 cases; destruction of a major portion of the intraluminal tumor was achieved in 17 patients, and incomplete destruction was possible in 9 patients. In 1 case, the treatment had no effect. Among 22 subjects in maintenance treatment, 13 good results were obtained. Several complications of laser therapy were observed: 2 cases of minor bleeding, 2 cases of esophagitis and 1 perforation of the upper esophagus. The patient died after surgery. Endoscopic YAG laser therapy for palliative treatment of esophageal and cardiac carcinoma is effective, providing rapid improvement of dysphagia. Maintenance treatment is necessary to sustain the improvement. Randomized studies are now needed to compare endoscopic laser therapy with other palliative treatment of malignant tumors of the upper gastrointestinal tract.

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Accession: 005359403

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