EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Endoscopic papillotomy a comparative analysis of the effects of ceruletide and octilonium bromide as modifiers of the motility of the duodenum and the papillary sphincter



Endoscopic papillotomy a comparative analysis of the effects of ceruletide and octilonium bromide as modifiers of the motility of the duodenum and the papillary sphincter



Medicina Clinica 89(6): 230-234



Endoscopic papillotomy (EP) is one of the fundamental application of endoscopic retrograde cholangio-pancreatography (ERCP). One of its major problems are the technical difficulties for its use; as a result, the efficacy of EP is limited in most studies to rates not exceeding 80-90% of cases. Both octilonium bromide and ceruletide have experimentally shown their ability to relax the second duodenal portion. The administration of these drugs may therefore facilitate the performance of both ERCP and EP and improve their rate of success. A randomized prospective double-blind study was designed to compare the efficacy of both drugs as facilitating medication for endoscopic papillotomy. 57 patients were included in the study, 28 of these received ceruletide and 29 received octilonium bromide. ERCP was achieved 93.2% of the whole group of patients, and papillotomy was performed in 41 out of the 46 cases where there was indication for it (89%), and it was successful in 82% of patients (38/46). To compare both groups of patients ERCP and EP were divided in different procedure phases. In the analysis of results, both drugs showed to be effective for the facilitation of both ERCP and EP. Although a tendency towards a higher efficacy of ceruletide was detected, the differences did not have statistical significance. Whereas the relaxation of the second duodenal portion was similarly effective in both groups, biliary reflux was more apparent in the group receiving ceruletide, showing the relaxing effect of this drug on the papillary sphyncter. From the comparative study of both drugs it can be concluded that they are similarly effective to relax the second duodenal portion and to facilitate the localization and deep cannulation of the common duct; in addition, there is a tendency for a higher efficacy of ceruletide in relaxing the papillary sphyncter.

(PDF emailed within 1 workday: $29.90)

Accession: 005359431

Download citation: RISBibTeXText



Related references

Endoscopic papillotomy. Comparative analysis of the effect of ceruletide and octylonium bromide as modifiers of the motility of the duodenum and the papillary sphincter. Medicina Clinica 89(6): 230-234, 1987

Studies on papillary function and effect of prifinium bromide and other antispasmodics on motility of the papillary region (sphincter of Oddi) in humans. Clinical Therapeutics 7(2): 154-163, 1985

Successful endoscopic treatment of extensive recurrent papillary stenosis six years after endoscopic papillotomy. Endoscopy 16(6): 246-248, 1984

Successful endoscopic treatment of extensive recurrent papillary stenosis 6 years after endoscopic papillotomy. Endoscopy 16(6): 246-248, 1984

Endoscopic balloon sphincteroplasty for benign papillary stenosis--an alternative to surgical or endoscopic papillotomy?. Irish Journal of Medical Science 162(9): 355-357, 1993

Effects of intravenous alcohol on motility of the duodenum and of the sphincter of Oddi. Australasian Annals of Medicine 19(1): 24-29, 1970

Endoscopic papillary dilation possible alternative to endoscopic papillotomy?. Gastroenterologie Clinique Et Biologique: 827, 1982

Endoscopic papillary dilatation, a possible alternative to endoscopic papillotomy. Lancet 1(8284): 1306-1307, 1982

Effects of ethanol on the motility of papillary sphincter and exocrine pancreas in the monkey. American Journal of Gastroenterology 88(12): 2078-2083, 1993

Endoscopic papillotomy in benign papillary stenosis. Schweizerische Medizinische Wochenschrift 112(15): 528-529, 1982

Endoscopic papillary dilatation: an alternative to papillotomy?. Deutsche Medizinische Wochenschrift 107(23): 895-897, 1982

Investigation of the sphincter of Oddi before, immediately after and six weeks after endoscopic papillotomy. Endoscopy 18(1): 14-16, 1986

Immediate effects of endoscopic sphincterotomy on sphincter of Oddi motility. Folia Medica Cracoviensia 41(3-4): 141-151, 2001

Immediate effects of the endoscopic sphincterotomy on the motility of the sphincter of Oddi. Arquivos de Gastroenterologia 25(4): 193-197, 1988

Effects of ethanol on pancreatic duct pressure and papillary sphincter motility in japanese monkeys. Japanese Journal of Smooth Muscle Research 26(6): 374-376, 1990