+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Endoscopic photoradiation therapy for esophageal cancer

Endoscopic photoradiation therapy for esophageal cancer

Gastroenterological Endoscopy 27(2): 177-181

Hematoporphyrin derivative (HpD) has an affinity for malignant tissues and shows cytocidal effects when it is excited by Argon-dye laser. This method is called photoradiation therapy (PRT). Effects of PRT on esophageal carcinoma were discussed. Four cases of superficial esophageal carcinoma underwent PRT. Histological studies on bite biopsy specimens from the lesions showed intraepithelial squamous cell carcinoma. Argon-dye laser was irradiated for 5 to 15 min with 300 to 500 mW power output at the tip of quartz fiber, under direct control of esophagofiber scope, after 48 h following i.v. administration of HpD (3mg/kg). Esophageal lesions showed white pseudomembranous changes after irradiation in 2 to 3 days, and they formed ulcers in 1 to 2 wk. Those ulcers healed within 3 mo. All cases were followed periodically by endoscopy for 11 to 17 mo. Histological studies on bite biopsy specimens from the lesions showed no malignancy. In these 4 cases, the results of PRT for esophageal cancer have been effective and satisfactory. Histopathological studies on resected specimen revealed the depth of PRT was mucosa and a part of submucosa. Thus, the effective depth of PRT reached to submucosa. The cases of superficial flat type and most of superficial erosive type by endoscopic diagnosis were within the depth of mucosa. The indication of PRT of esophageal carcinoma is as follows: superficial flat type and most of superficial erosive type by endoscopic diagnosis.

(PDF emailed within 1 workday: $29.90)

Accession: 005359446

Download citation: RISBibTeXText

Related references

Fundamental studies on photoradiation therapy effects of photoradiation therapy on cultured human cancer cell lines. Acta Obstetrica et Gynaecologica Japonica (Japanese Edition) 38(6): 863-870, 1986

Symposium 2 cancer treatment by laser in the tracheo esophageal region d. endoscopic photodynamic therapy for esophageal cancer. Journal of the Japan Broncho Esophagological Society 40(2): 118-121, 1989

Endoscopic therapy of neoplasia related to Barrett's esophagus and endoscopic palliation of esophageal cancer. Cancer Control 20(2): 117-129, 2013

Analysis of endoscopic appearance and a re-staging endoscopic ultrasound after neo-adjuvant therapy in the management of esophageal cancer. American Journal of Gastroenterology 95(9): 2427-2428, September, 2000

Palliation of esophageal malignancy with photoradiation therapy. Cancer 54(12): 2905-2910, 1984

Endoscopic therapy using an endoscopic variceal ligation for minute cancer of the esophagogastric junction complicated with esophageal varices: a case report. Journal of Medical Case Reports 4(): 149-149, 2010

Photoradiation therapy (PRT). 2. Mechanism of tumor-cell killing effect of photoradiation therapy. Nihon Rinsho. Japanese Journal of Clinical Medicine 45(4): 769-775, 1987

Complications of endoscopic dilation for esophageal stenosis after endoscopic submucosal dissection of superficial esophageal cancer. Surgical Endoscopy 29(10): 2953-2959, 2016

A comparison of endoscopic laser therapy and BICAP tumor probe therapy for esophageal cancer. American Journal of Gastroenterology 82(7): 608-612, 1987

Endoscopic therapy of esophageal cancer. Surgical Clinics of North America 77(5): 1197-1217, 1997

Endoscopic Therapy for Esophageal Cancer. Kyobu Geka. Japanese Journal of Thoracic Surgery 69(8): 718-723, 2016

Endoscopic laser therapy one component of therapy for esophageal cancer. Contemporary Surgery 40(4): 15-19, 1992

Outcomes of Surgical Resection of T1bN0 Esophageal Cancer and Assessment of Endoscopic Mucosal Resection for Identifying Low-Risk Cancers Appropriate for Endoscopic Therapy. Annals of Surgical Oncology 23(8): 2673-2678, 2016

Photoradiation therapy (PRT). 7. Clinical study of photoradiation therapy: clinical application and efficacy. a. Clinical application and the efficacy of photoradiation therapy on digestive system neoplasms. Nihon Rinsho. Japanese Journal of Clinical Medicine 45(4): 800-805, 1987

Esophageal stent fixation with endoscopic suturing device improves clinical outcomes and reduces complications in patients with locally advanced esophageal cancer prior to neoadjuvant therapy: a large multicenter experience. Surgical Endoscopy (): -, 2016