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Endoscopic photoradiation therapy for esophageal cancer



Endoscopic photoradiation therapy for esophageal cancer



Gastroenterological Endoscopy 27(2): 177-181



Hematoporphyrin derivative (HpD) has an affinity for malignant tissues and shows cytocidal effects when it is excited by Argon-dye laser. This method is called photoradiation therapy (PRT). Effects of PRT on esophageal carcinoma were discussed. Four cases of superficial esophageal carcinoma underwent PRT. Histological studies on bite biopsy specimens from the lesions showed intraepithelial squamous cell carcinoma. Argon-dye laser was irradiated for 5 to 15 min with 300 to 500 mW power output at the tip of quartz fiber, under direct control of esophagofiber scope, after 48 h following i.v. administration of HpD (3mg/kg). Esophageal lesions showed white pseudomembranous changes after irradiation in 2 to 3 days, and they formed ulcers in 1 to 2 wk. Those ulcers healed within 3 mo. All cases were followed periodically by endoscopy for 11 to 17 mo. Histological studies on bite biopsy specimens from the lesions showed no malignancy. In these 4 cases, the results of PRT for esophageal cancer have been effective and satisfactory. Histopathological studies on resected specimen revealed the depth of PRT was mucosa and a part of submucosa. Thus, the effective depth of PRT reached to submucosa. The cases of superficial flat type and most of superficial erosive type by endoscopic diagnosis were within the depth of mucosa. The indication of PRT of esophageal carcinoma is as follows: superficial flat type and most of superficial erosive type by endoscopic diagnosis.

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Accession: 005359446

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