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Endoscopic view of indomethacin induced gastric mucosal damage in man its' relation with the mucosal prostaglandin level



Endoscopic view of indomethacin induced gastric mucosal damage in man its' relation with the mucosal prostaglandin level



Gastroenterological Endoscopy 29(2): 254-260



Six healthy volunteers were tested the effect of indomethacin in a dose of clinical use on gastric mucosal damage and the levels of mucosal prostaglandins (PGs). In three out of 6 subjects, gastric mucosal lesions induced by indomethacin were endoscopically found; two spotty hemorrhagic erosions in gastric antrum in one of the subjects; five linear hemorrhagic erosions in angle and corpus in another one; multiple hemorrhage erosions in whole stomach in the last one. The PGE2 level determined from biopsy specimens was significantly reduced by the administration of indomethacin both in corpus and antrum of the stomach. The level of 6-keto-PGF1.alpha. (the final metabolite of PGI2) was also reduced by indomethacin, but not significant. These results suggest that clinical dose indomethacin decreases mucosal integrity in relation to the reduction of prostanoids in gastric mucosa of healthy subjects.

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Accession: 005359732

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