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Endosulfan induced inhibition of tritiated 5 hydroxytryptamine uptake in platelets



Endosulfan induced inhibition of tritiated 5 hydroxytryptamine uptake in platelets



Toxicology Letters (Shannon) 32(3): 203-208



Endosulfan, a chlorinated pesticide, is widely used to control various insect pests. Rats exposed to 1 mg and 3 mg endosulfan/kg for periods of 10, 30 mand 60 days showed significant (P < 0.05) inhibition of [3H]5-hydroxytryptamine (5-HT) uptake by platelet-rich plasma (PRP) in an ex vivo study. Rats treated with endosulfan (1 and 3 mg/kg) up to 60 days elucidated a marked inhibition of ADP-induced aggregatory responses of the platelets. Incubation of PRP with 10 .mu.M and 100 .mu.M endosulfan for 15 min at 37.degree. c also resulted in significant (P < 0.05) inhibition of platelet aggregation in vitro. The paper discusses the use of rat blood platelets as a model for the study of neuro- and cardiovascular toxicity of endosulfan.

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Accession: 005359841

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