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Endosulfan intoxication blood glucose electrolytes calcium levels ascorbic acid and glutathione in rats



Endosulfan intoxication blood glucose electrolytes calcium levels ascorbic acid and glutathione in rats



Toxicology Letters (Shannon) 5(2): 119-124



Changes in blood glucose, plasma electrolytes, and blood and brain ascorbic acid, hexokinase and glutathione, induced by the pesticide endosulfan, were investigated following acute and subacute administration in 12 h fasted male rats. After a single oral dose of endosulfan (40 mg/kg) a significant increase in blood glucose, blood ascorbic acid, and blood and brain glutathione was observed. The maximum increase in blood glucose was observed at 2 h (36%). Increase in blood and brain glutathione was highly significant at 4 h (50 and 43%, respectively). The blood ascorbic acid slowly increased by 19% over controls during the treatment period. No significant change in brain hexokinase was observed. Repeated oral administration of endosulfan (0.625-20 mg/kg) for 7 wk had no effect on plasma Na and K. At the highest dose (20 mg/kg), blood glucose was slightly increased (16%). Plasma Ca was significantly decreased, the maximum fall (35%) being observed at 4 h.

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Accession: 005359842

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