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Endothelial cell cytotoxicity in inflammatory vascular diseases the possible role of oxidized lipoproteins



Endothelial cell cytotoxicity in inflammatory vascular diseases the possible role of oxidized lipoproteins



Annals of the Rheumatic Diseases 44(3): 176-182



One of the proposed mechanisms of vascular damage in connective tissue disease is the direct action of a cytotoxic serum factor inducing endothelial cell damage. The nature of this serum factor is unclear, but was suggested to be a lipoprotein. Sera from patients with systemic necrotizing arteritis (polyarteritis nodosa, Wegener's granulomatosis and necrotizing arteritis associated with rheumatoid synovitis), systemic or joint restricted rheumatoid disease and large vessel/giant cell arteritis have been examined for cytotoxicity to human cultured endothelial cells and azide-resistant ferroxidase-like activity (indicative of the oxidized lipoprotein content). Stored sera from patients with necrotizing arteritis showed a significantly enhanced tendency to develop oxidized lipoprotein, which correlated closely with human endothelial cell cytotoxicity. Fresh sera also contained this factor, but to a lesser extent. The cytotoxic factor detected in previous clinical studies is in part an in-vitro artifact, although its accelerated development in certain patient groups might suggest an excess of pro-oxidants that developed in vivo.

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Accession: 005359885

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PMID: 3977420



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