+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Endothelial cell phenotypic diversity. In situ demonstration of immunologic and enzymatic heterogeneity that correlates with specific morphologic subtypes

Endothelial cell phenotypic diversity. In situ demonstration of immunologic and enzymatic heterogeneity that correlates with specific morphologic subtypes

American Journal of Clinical Pathology 87(5): 569-575

Some endothelial cells share functional and phenotypic properties with cells of monocyte/macrophage lineage. The authors have performed frozen-section immunologic stains and plastic section enzyme histochemical stains on various human tissues to examine endothelial cell phenotypic properties in situ. They found that endothelial cells express heterogeneous phenotypes that correlate with vessel type. Several endothelial cell subsets were identified. These included arterioles, capillaries, and venules (HLA-ABC+, HLA-DR+, Factor VIII RA+, monocyte-, alkaline phosphatase+, ATPase+); high endothelial venules of lymphoid tissues and hepatic sinusoidal lining cells (HLA-ABC+, HLA-DR+, Factor VIII RA+, monocyte+); lymphatics and glomerular capillaries (HLA-ABC+, HLA-DR+/-, Factor VIII RA-, monocyte-, 5'-nucleotidase+); splenic sinusoidal lining cells (HLA-ABC+, Leu-2+, HLA-DR+, Factor VIII RAweak+, monocyte-, alpha naphthyl acetate esterase+); umbilical cord vessels (Factor VIII RA+, HLA-ABCweak+, HLA-DR- monocyte-). The expression of monocyte-related antigens by some endothelial cells appears to be acquired in extranodal inflammatory infiltrates and is probably modulated by lymphokines.

(PDF emailed within 0-6 h: $19.90)

Accession: 005359936

Download citation: RISBibTeXText

PMID: 3554972

DOI: 10.1093/ajcp/87.5.569

Related references

Histiocytic malignancies. Morphologic, immunologic, and enzymatic heterogeneity. American Journal of Surgical Pathology 8(7): 485-500, 1984

In situ demonstration of immunological heterogeneity in vascular endothelial cells of renal cell carcinoma. Journal of Surgical Oncology 43(2): 73-78, 1990

Endothelial cell heterogeneity in the normal human liver acinus: In situ immunohistochemical demonstration. Liver 14(3): 113-123, 1994

Endothelial cell heterogeneity in experimentally-induced rabbit atherosclerosis: Demonstration of multinucleated giant endothelial cells by scanning electron microscopy and cell culture. Virchows Archiv 425(5): 521-529, 1994

Interdigitating reticulum cell sarcoma 2 cases with supportive morphologic immunologic and enzymatic findings. Laboratory Investigation 52(1): 70A-71A, 1985

Phenotypic diversity of organ-specific endothelial cells. Proceedings of the American Association for Cancer Research Annual Meeting 42: 406, March, 2001

Heterogeneity and phenotypic instability of chemotherapeutic and immunologic sensitivity in murine and human melanoma cell clones. Tumori 78(1): 5-9, 1992

Phenotypic heterogeneity of t cell malignancies demonstration by mono clonal antibodies and enzyme histochemistry. Laboratory Investigation: 35a, 1981

Phenotypic heterogeneity of human T-cell malignancies: demonstration by monoclonal antibodies and cytochemical markers. American Journal of Hematology 12(3): 233-245, 1982

The expression pattern of T cell-associated chemokine receptors correlates with specific subtypes of T cell lymphoma. Blood 94(10 SUPPL 1 PART 1): 304a, Nov 15, 1999

Tissue- and site-specific gene expression of type 2 17beta-hydroxysteroid dehydrogenase: In situ hybridization and specific enzymatic activity studies in human placental endothelial cells of the arterial system. Journal of Clinical Endocrinology & Metabolism 85(12): 4841-4850, December, 2000

Spatial heterogeneity of endothelial phenotypes correlates with side-specific vulnerability to calcification in normal porcine aortic valves. Circulation Research 96(7): 792-799, 2005

Expression pattern of T-cell-associated chemokine receptors and their chemokines correlates with specific subtypes of T-cell non-Hodgkin lymphoma. Blood 96(2): 685-690, 2000