+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Endothelial cell proliferation and monocyte adhesion to atherosclerotic lesions of white carneau pigeons

Endothelial cell proliferation and monocyte adhesion to atherosclerotic lesions of white carneau pigeons

American Journal of Pathology 125(1): 152-160

Two of the early changes that occur at sites of developing atherosclerotic lesions in pigeon aortas are monocyte adhesion and endothelial proliferation. We characterized these events in the abdominal aortas of lesion-free young pigeons and in mature birds that developed either naturally occurring or cholesterol-induced atherosclerosis. Compared with mature animals, very young (7-day-old) pigeons had elevated endothelial cell labeling with 3H-thymidine in normal regions of aorta as quantitated by scanning electron microscopy. All regions of atherosclerosis exhibited at least a fivefold increase in both monocyte adhesion and endothelial proliferation. Adhesion and proliferation were highest at the developing edge of lesions. When naturally occurring lesions of 5-year-old birds were compared with lesions of younger birds fed a 0.5% cholesterol-supplemented diet for either 15 or 52 weeks, monocyte adhesion and endothelial cell proliferation were found to be similar. The same parameters were studied after regression of atherosclerosis in pigeons fed 0.5% cholesterol-supplemented diet for 1 year, followed by cholesterol-free diet for 2, 6, or 11 months. The regression regimen resulted in significant reduction in both monocyte adhesion and endothelial proliferation at lesion sites. It is concluded that progressing atherosclerotic lesions, whether occurring naturally or exacerbated by cholesterol feeding, have similar and significant increases in monocyte adhesion and endothelial cell proliferation. Regression of atherosclerotic lesions is accompanied by a decrease in these two cellular events.

(PDF emailed within 1 workday: $29.90)

Accession: 005359940

Download citation: RISBibTeXText

PMID: 3777132

Related references

Cellular dynamics in early atherosclerotic lesion progression in white carneau pigeons. Spatial and temporal analysis of monocyte and smooth muscle invasion of the intima. Arteriosclerosis, Thrombosis, and Vascular Biology 17(4): 654-664, 1997

Influx, efflux, and accumulation of LDL in normal arterial areas and atherosclerotic lesions of white Carneau pigeons with naturally occurring and cholesterol-aggravated aortic atherosclerosis. Arteriosclerosis and Thrombosis 13(9): 1368-1381, 1993

A cytokine induced human endothelial cell monocyte adhesion molecule expressed in vessels with atherosclerotic lesions. FASEB Journal 5(5): A1438, 1991

Endothelial CSN5 impairs NF-κB activation and monocyte adhesion to endothelial cells and is highly expressed in human atherosclerotic lesions. Thrombosis and Haemostasis 110(1): 141-152, 2014

Location and sequence of atherosclerotic plaque formation in white Carneau and show racer pigeons. Archives of Pathology and Laboratory Medicine 102(11): 581-586, 1978

Panax notoginseng reduces atherosclerotic lesions in ApoE-deficient mice and inhibits TNF-alpha-induced endothelial adhesion molecule expression and monocyte adhesion. Journal of Agricultural and Food Chemistry 57(15): 6692-6697, 2009

Monocyte migration induced by lesion homogenates from athero sclerotic aortas of white carneau pigeons. Journal of Cell Biology 97(5 PART 2): 423A, 1983

Location and sequence of atherosclerotic plaque formation in white Carneau and show racer pigeons: reevaluation and redefinition. Archives of Pathology & Laboratory Medicine 102(11): 581-586, 1978

Monocyte/macrophage recruitment and expression of endothelial adhesion proteins in human atherosclerotic lesions. Atherosclerosis. 121(2): 253-266, 1996

Role of vascular cell adhesion molecule-1 and fibronectin connecting segment-1 in monocyte rolling and adhesion on early atherosclerotic lesions. Circulation Research 87(2): 153-159, 2000

Smooth muscle cells: the source of foam cells in atherosclerotic white Carneau pigeons. Experimental and Molecular Pathology 8(2): 171-189, 1968

Early atherogenesis in white carneau pigeons 1. leukocyte margination and endothelial alterations at the celiac bifurcation. American Journal of Pathology 116(1): 56-68, 1984

Endothelial cells morphology at select sites in coronary athero sclerosis susceptible white carneau pigeons. Arteriosclerosis 1(1): 58-59, 1981

Effect of endothelial cell proliferation on atherogenesis: a role of p21(Sdi/Cip/Waf1) in monocyte adhesion to endothelial cells. Atherosclerosis 212(1): 116-122, 2010