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Enhanced pathogenicity of chicken anemia agent in dual infections with marek's disease virus and infectious bursal disease virus or reticuloendotheliosis virus



Enhanced pathogenicity of chicken anemia agent in dual infections with marek's disease virus and infectious bursal disease virus or reticuloendotheliosis virus



Journal of Veterinary Medicine Series B 33(2): 93-116



Day-old chickens were infected by intramuscular inoculation of chicken anaemia agent (CAA) alone, or dually infected with CAA and Marek's disease virus (MDV), infectious bursal disease virus (IBDV), or reticuloendotheliosis virus (REV). Single CAA infection caused within two weeks a pronounced anaemia associated with distinct atrophy of bone marrow and thymus in virtually all birds, but mortality did not exceed 30%. Histopathological lesions were characterized by panmyelophthisis, including atrophy of bone marrow and a generalized atrophy of all lymphoid organs and tissues. Dual infections generally resulted in the same but more pronounced lesions, increased mortality, and partly in delayed reconvalescence. The enhanced pathogenicity of CAA in dually infected birds is thought to be due to immunosuppression induced by MDV as well as by IBDV or REV. Protection by anti-CAA maternal antibody can obviously be overcome by dual infection, at least with IBDV and CAA. High susceptibility of CAA-infected chicks to secondary bacterial infections in the presence of generalized lymphoid atrophy is considered to be indicative of immunodepressive effects of CAA infection. Results are discussed with reference to the probable aetiological participation of CAA in a syndrome of panmyelopathy, haemorrhagic diathesis and dermatitis which mainly affect broiler chickens.

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Accession: 005363358

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Enhanced pathenogicity of chicken anemia agent (CAA) in dual infections with Marek's disease virus (MDV), infectious bursal disease virus (IBDV) or reticuloendotheliosis virus (REV). Zentralblatt für Veterinarmedizin. Reihe B. Journal of Veterinary Medicine. Series B 33(2): 93, 1986

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