Enhancement of rectal absorption of insulin in poly acrylic acid aqueous gel bases containing long chain fatty acid in rats

Morimoto, K.; Kamiya, E.; Takeeda, T.; Nakamoto, Y.; Morisaka, K.

International Journal of Pharmaceutics 14(2-3): 149-158

1983


ISSN/ISBN: 0378-5173
Accession: 005365361

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Abstract
The effect of the polyacrylic acid aqueous gel base containing one of 3 kinds of long-chain fatty acids (LCFA (oleic acid, linolic acid and linolenic acid) at various concentrations (none, 0.1, 1, 2, and 5% v/v [vol/vol])) was investigated by a rectal administration of insulin to rats. The hypoglycemic effects of insulin in gel bases containing each LCFA were stronger than that of simple gel (none containing LCFA) at an insulin dose of 1 IU/kg. The maximum hypoglycemic effect was obtained with gel base containing each LCFA at 1% v/v at 1 h after administration. The hypoglycemic effects, in order of strength, were 1% > 0.1% > 2% > 5% (v/v) > none of each LCFA, and were similar between the 3 kinds of LCFA. Plasma insulin levels reached a peak during the first 30 min and were dose-dependent for the gel base containing LCFA at 1% v/v. When insulin was administered with a polyacrylic acid aqueous gel base containing LCFA, the absorption of insulin was promoted.