Section 6
Chapter 5,372

Enzyme activities and genetic polymorphism in mice as model animal under the effect of selection for endurance and protein deposition part 2 studies of enzyme activities in blood plasma up to the 13th selection generation

Major, F.; Tawfik, E.S.

Zeitschrift fuer Tierzuechtung und Zuechtungsbiologie 95(3-4): 278-286


Accession: 005371212

Selection generations (13) were studied to analyze the effects of selection for endurance (time of survival under physical stress) and for protein deposition (total protein in carcass) at 60 days of age in mice on enzyme activities in blood plasma in 2 subpopulations. The enzymes studied were creatine phosphokinase (CK), alkaline phosphatase (AP), glucose-6-phosphate dehydrogenase (G6P-DH), lactate dehydrogenase (LDH), lactate dehydrogenase-1-isoenzyme (LDH 1) and fructose-1,6-diphosphataldolase (ALD). Analysis of variance indicated direction of selection and generation to be significant for all enzyme activities studied. There was no consistent difference for CK, LDH, LDH1, G6P-DH and ALD between the lines selected for positive and negative endurance or protein deposition. Significant differences in the enzyme activities in both subpopulations were obtained only for AP due to the selection for protein deposition. In case of selection for endurance a significant difference for AP between the positive and negative line was found only in subpopulation 2. Estimates of correlations between the enzyme activities and body wt were computed for all data after correcting for the main sources of variance. The correlations between body wt and activity of the enzymes CK, LDH, LDH1, G6P-DH and ALD were very low. The highest coefficient found was that for the phenotypic relation between AP and body wt (rp = .sbd.0.32***).

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