Section 6
Chapter 5,374

Enzymic formation of beta alkyl glycosides by beta galactosidase from aspergillus oryzae and its application to the synthesis of chemically unstable cardiac glycosides

Ooi, Y.; Hashimoto, T.; Mitsuo, N.; Satoh, T.

Chemical and Pharmaceutical Bulletin 33(5): 1808-1814


ISSN/ISBN: 0009-2363
DOI: 10.1248/cpb.33.1808
Accession: 005373504

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.beta.-Galactosidase obtained from A. oryzae had strong transglycosylation activity. The glycosylation of water-soluble and insoluble alcohols was successfully performed under mild conditions (pH 5 at 4-37.degree. C) with this enzyme. The enzyme was also applied to the one-step synthesis of several cardiac glycosides that are difficult to obtain by ordinary chemical methods.

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