EurekaMag.com logo
+ Site Statistics
References:
53,214,146
Abstracts:
29,074,682
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Epidemiological analysis of neisseria gonorrhoeae in west germany by auxotyping and serological classification using monoclonal antibodies






Genitourinary Medicine 62(3): 145-150

Epidemiological analysis of neisseria gonorrhoeae in west germany by auxotyping and serological classification using monoclonal antibodies

We evaluated a new serological classification system for Neisseria gonorrhoeae based on monoclonal antibodies directed against epitopes on the outer membrane protein I, in conjunction with auxotyping, to analyse gonococci from two cities in the Federal Republic of Germany. Isolates of N. gonorrhoeae were collected during 1976-8 and 1980-2 in Lubeck, and during 1980-2 in Heidelberg. Between the two study periods in Lubeck, we observed an appreciable decrease in strains of the auxotype that requires arginine, hypoxanthine, and uracil (AHU-) and with serovar class PrIA-1 and the emergence of strains with the proline requiring auxotype and PrIB-I serovar class. Serovar PrIA-1 accounted for 89 (97%) of 92 strains with the AHU- auxotype as opposed to 12 (4%) of 297 strains with other auxotypes (p < 0.0001). Disseminated gonococcal infection was associated with AHU-/PrIA-1 strains. Penicillinase producing N. gonorrhoeae (PPNG) strains belonged to eight different auxotype and serovar classes, which indicated that different strains had been imported. Classification of strains of N. gonorrhoeae by auxotype and serovar class permits analysis of temporal changes in gonococcal populations, and of migrations of gonococci between different geographical areas. Typing N. gonorrhoeae, together with assessing susceptibilities, may prove useful for further studies of the epidemiology and control of gonorrhoea.

(PDF 0-2 workdays service: $29.90)

Accession: 005375006



Related references

Epidemiological analysis of Neisseria gonorrhoeae in the Federal Republic of Germany by auxotyping and serological classification using monoclonal antibodies. Genitourinary Medicine 62(3): 145-150, 1986

Comparison between serological classification and auxotyping in the analysis of Neisseria gonorrhoeae infections. Acta Pathologica, Microbiologica, et Immunologica Scandinavica. Section B, Microbiology 95(3): 181-188, 1987

Serological classification of Neisseria gonorrhoeae with monoclonal antibodies. Infection and Immunity 36(3): 1042-1053, 1982

Serological classification of Neisseria gonorrhoeae with use of monoclonal antibodies to gonococcal outer membrane protein I. Journal of Infectious Diseases 150(1): 44-48, 1984

Auxotyping of Neisseria gonorrhoeae as an additional epidemiological marker. Indian Journal of Medical Research 95: 227-229, 1992

Serological classification of Neisseria gonorrhoeae. Clinical and epidemiological applications. Antonie van Leeuwenhoek 53(6): 375-380, 1987

Serological classification of Neisseria gonorrhoeae with monoclonal antibody coagglutination reagents. Genitourinary Medicine 63(4): 225-232, 1987

Epidemiological characterization of Neisseria gonorrhoeae isolates from Taiwan. Part II: Distribution of auxotyping, serogrouping and plasmid profile. Taiwan Yi Xue Hui Za Zhi. Journal of the Formosan Medical Association 88(7): 734-739, 1989

Serogrouping and auxotyping for epidemiological study of beta-lactamase-producing Neisseria gonorrhoeae strains isolated in Sweden. Acta Dermato-Venereologica 61(4): 329-334, 1981

Serological classification and epidemiology of neisseria gonorrhoeae using mono clonal antibodies. Abstracts of the Annual Meeting of the American Society for Microbiology 83: C28, 1983