EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Epidemiological assessment of occupationally related, chemically induced sperm count suppression


Journal of Occupational Medicine. 22(2): 77-82
Epidemiological assessment of occupationally related, chemically induced sperm count suppression
Occupationally related, chemically induced sperm count suppression is a recently recognized problem, first brought to light in connection with the manufacture and formulation of dibromochloropropane (DBCP). The authors studied sperm count data from four occupational cohorts - two exposed to DBCP and two exposed to epichlorohydrin (ECH). In both DBCP cohorts there was a significant difference (alpha = 0.05) between sperm count distribution functions of the exposed group and of the non-exposed group. A much higher percentage of exposed men was oligospermic and the median sperm count for each exposed group was substantially lower than that for the respective non-exposed group. In the ECH cohorts there was no significant difference between sperm count data for the exposed group and for the non-exposed group. The authors concluded that exposure to DBCP, but not to ECH, was positively associated with detectable sperm count suppression. It is suggested that the key to identifying and assessing occupationally related sperm count suppression lies in the proper classification and interpretation of group sperm count data.


Accession: 005375163

PMID: 7373445

DOI: 10.1097/00043764-198002000-00003



Related references

Declining sperm count and fertility in males: an epidemiological controversy. Archives of Andrology 41(1): 27-30, 1998

Declining sperm count and fertility in males: An epidemiological controversy. Archives of Andrology 41(1): 27-30, 1998

Outbreaks of occupationally associated skin disease with particular reference to chemically induced depigmentation occupational vitiligo. Annals of Occupational Hygiene 31(1): 96-97, 1987

The use of an in vitro sperm activation assay to detect chemically induced damage of human sperm nuclei. Reproductive Toxicology 9(4): 351-357, 1995

Sperm count suppression without endocrine dysfunction in lead-exposed men. Archives of Environmental Health 42(2): 124-127, 1987

The chromosomal risk in sperm from heterozygous Robertsonian translocation carriers is related to the sperm count and the translocation type. Fertility and Sterility 96(6): 1337-1343, 2012

Variability in sperm suppression during testosterone administration to adult monkeys is related to follicle stimulating hormone suppression and not to intratesticular androgens. Journal of Clinical Endocrinology and Metabolism 87(7): 3399-3406, 2002

Laboratory assessment of the immune system in individuals occupationally exposed to 2 3 7 8 tetrachlorodibenzo p dioxin 2 3 7 8 tcdd quality control in a cross sectional epidemiological study. Chemosphere 18(1-6): 867-874, 1989

Correlations between genital tract changes, total sperm count per ejaculate, and organ findings in bulls of the Artificial Insemination Center, Neuchatel. II. Statistical studies of sperm count and testicular changes in 159 Simmental bulls. Schweizer Archiv für Tierheilkunde 117(8): 425-437, 1975

Progress in clinical and biological research vol 369 chemically induced cell proliferation implications for risk assessment chemically induced cell proliferation conference austin texas usa november 29 december 2 1989. Butterworth, B E , Et Al Progress in Clinical And Biological Research, Vol 369 Chemically Induced Cell Proliferation: Implications For Risk Assessment; Chemically Induced Cell Proliferation Conference, Austin, Texas, Usa, November 29-December 2, 1989 Xxiii+547p Wiley-Liss, Inc : New York, New York, Usa; Chichester, England, Uk Illus Xxiii+547p, 1991