EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Epidemiological data on cervical carcinoma relevant to cytopathology


Applied Pathology 5(1): 25-32
Epidemiological data on cervical carcinoma relevant to cytopathology
Epidemiological studies based on cervical cytopathology have aroused wide-spread interest since it was realized that they could be a useful tool for measuring the effectiveness of screening programs and defining practical measures for the prevention of invasive neoplasms and deaths. In the present article, published evidence from screening programs, cohort investigations and case-control studies is reviewed, and possibilities for further analyses and applications are discussed. In particular, when estimates of the relative protections conveyed by Pap smear from various case-control studies conducted on different populations and using different criteria of selection were pooled, a surprisingly close concordance emerged, with overall risk estimates of invasive cervical cancer of 0.42 for women reporting one smear, and of 0.20 for two or more smears in the past. This protection appeared to be long-lasting in a considerable proportion of cases, since the major determinant of invasive cancer risk was the number of previous smears rather than the interval since last smear, and a noticeable residual effect was evident even more than 10 years after the last smear. Besides providing a measure of the effectiveness of cytological screening and helping define the optimal frequency of screening using the limited resources available, case-control studies should permit accurate estimates of the sensitivity of the test and quantify the probability of transition and the duration of various stages of the neoplastic process, i.e., permit a better understanding of the natural history of the disease.


Accession: 005375221

PMID: 3620205



Related references

Cervical carcinoma and reproductive factors: collaborative reanalysis of individual data on 16,563 women with cervical carcinoma and 33,542 women without cervical carcinoma from 25 epidemiological studies. International Journal of Cancer 119(5): 1108-1124, 2006

Cervical carcinoma and sexual behavior: collaborative reanalysis of individual data on 15,461 women with cervical carcinoma and 29,164 women without cervical carcinoma from 21 epidemiological studies. Cancer Epidemiology, Biomarkers & Prevention 18(4): 1060-1069, 2009

An overview of the College of American Pathologists' programs in surgical pathology and cytopathology. Data summary of diagnostic performance in cervical cytopathology. Acta Cytologica 33(4): 439-442, 1989

An overview of the college of american pathologists programs in surgical pathology and cytopathology data summary diagnostic performance in cervical cytopathology. Acta Cytologica 33(4): 439-442, 1989

Carcinoma of the cervix and tobacco smoking: Collaborative reanalysis of individual data on 13,541 women with carcinoma of the cervix and 23,017 women without carcinoma of the cervix from 23 epidemiological studies - International collaboration of epidemiological studies of cervical cancer. International Journal of Cancer 118(6): 1481-1495, 2006

Cytopathology of false negatives preceding cervical carcinoma. American Journal Of Obstetrics & Gynecology. 175(4 Part 2): 1110-1113, 1996

Cytopathology of cervical aquamous carcinoma in situ in postmenopousal women. Acta Cytologica 14(7): 363-369, 1970

Quality control in cytopathology applied to screening for cervical carcinoma. Polish Journal of Pathology 46(4): 245-248, 1995

Combining PM2.5 Component Data from Multiple Sources: Data Consistency and Characteristics Relevant to Epidemiological Analyses of Predicted Long-Term Exposures. Environmental Health Perspectives 123(7): 651-658, 2016

Epidemiological data of different human papillomavirus genotypes in cervical specimens of HIV-1-infected women without history of cervical pathology. Journal of Acquired Immune Deficiency Syndromes 50(2): 168-175, 2009