+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Epidemiological factors related to the malignant neoplasms in ataxia telangi ectasia families

Journal of Chronic Diseases 31(9-10): 625-634
Epidemiological factors related to the malignant neoplasms in ataxia telangi ectasia families
In response to the demonstration of an increased risk of death from specific neoplasms among the blood relatives of patients homozygous for ataxia-telangiectasia (A-T) a review of the epidemiology of selected neoplasms and its application to the A-T relatives' mortality experience is presented. Demographic, social and medical factors associated with cancers of the gall bladder and bile ducts, ovary and stomach do not explain the increased number or the unusually early age of onset of these malignancies observed among the A-T family members. Although this analysis is limited in scope and reflects a univariate approach to the etiology of the various cancers considered, it supports a genetic basis for an increased susceptibility to malignant neoplasms among A-T heterozygotes.

Accession: 005375260

PMID: 744793

Related references

Epidemiologic factors as related to specific neoplasms in ataxia telangi ectasia families. American Journal of Epidemiology 104(3): 331-332, 1976

Chromosome studies in families with ataxia telangi ectasia. American Journal of Human Genetics 27(6): 27A, 1975

Ataxia telangi ectasia a multi parameter analysis of 8 families. Clinical Immunology & Immunopathology 23(2): 501-516, 1982

Genetic and immunologic study of 2 families with ataxia telangi ectasia of louis bar. Acta Neurologica (Naples) 25(5): 551-577, 1970

Pancreatic carcinoma and diabetes mellitus in families of ataxia telangi ectasia probands. American Journal of Human Genetics 24(6 PART 1): 48A, 1972

Ataxia telangi ectasia with immuno deficiency and malignant lymphoma 2 cases. Medicina Clinica 76(3): 109-112, 1981

Ataxia telangi ectasia with mixed immuno deficiency and related forms. Journal De Genetique Humaine: 281-299, 1975

Repair of gamma induced and bleomycin induced dna damage in ataxia telangi ectasia patients and families. Journal of Supramolecular Structure & Cellular Biochemistry (SUPPL 5): 200, 1981

Colony forming ability of ataxia telangi ectasia skin fibroblasts in an indicator of their early senescence and increased demand for growth factors. Experimental Cell Research 140(1): 191-200, 1982

Bleeding gastric telangi ectasia complication of raynauds phenomenon esophageal motor dys function sclero dactyly and telangi ectasia syndrome. American Journal of Gastroenterology 75(5): 354-356, 1981