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Epidemiological studies on the Sashima hepatitis (viral hepatitis) with reference to its etiological aspect

Nihon Ika Daigaku Zasshi 50(4): 547-562
Epidemiological studies on the Sashima hepatitis (viral hepatitis) with reference to its etiological aspect
An epidemiological investigation was performed on the type of hepatitis which mainly prevailed in the Sashima District, Ibaraki Prefecture, Japan, from Jan., 1962 to July, 1968. The main clinical feature of this hepatitis was that the disease was seen in the 30-50 yr old age groups. No patients were encountered in the 10 yr old age group. The mortality of this hepatitis was estimated at 9.7%, which is much higher than other reported hepatitis epidemics. Of 360 patients who were able to be included in the follow-up study, 225 cases showed persistent liver dysfunction > 5 yr after onset of the disease. The sero-immunological study revealed that 99 of 334 cases were negative for hepatitis B (HB). Cases (36) were determined to have superimposed infection of hepatitis B virus (HBV) in the follow-up study of the hepatitic condition. It was disclosed that some cases were hepatitis A antibody negative out of the HB negative subjects. The above-mentioned observations may support a view that the most cardinal point in the initial stage of this specific disease entity was the prevalence of (epidemic) the non-A, non-B type hepatitis, which showed superimposition of the type B hepatitis in the later stage. It would be noteworthy that no hitherto reported cases of the hepatitis epidemic was documented in this particular case which may be caused by 2 intermingled etiological factors.

Accession: 005375521

PMID: 6415089

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