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Epidemiological study of hemorrhagic fever with renal syndrome related virus infection among urban rats rattus norvegicus in 2 islands in tokyo bay japan

, : Epidemiological study of hemorrhagic fever with renal syndrome related virus infection among urban rats rattus norvegicus in 2 islands in tokyo bay japan. Acta Virologica 29(1): 66-72

A seroepidemiological survey of hemorrhagic fever with renal syndrome (HFRS) virus infection in 403 urban rats (R. norvegicus) captured on 2 different islands in Tokyo Bay was carried out using the indirect immunofluorescent antibody (IFA) test with the SR-11 strain of HFRS virus. Antibody positive sera were detected in 99 of 355 (27.9%) rats from the island with reclaimed ground area, but none were detected in 48 rats from the other islands. IFA titers of the positive sera varied from 16-4096 (mostly 128) with a peak at 1:128, and antibody positive ratios were significantly higher in the small rats (< 50 g, probably of younger age) than in the large ones. A causative agent antigenically related to HFRS virus was isolated from lung tissue of a seropositive rat using Vero-E6 cells. These results revealed the existence of HFRS related virus among urban rats in the coast of Tokyo Bay, Japan.

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