+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Epidemiological study of the morphogenetic relationship between adenoma and large intestinal cancer

Arkhiv Patologii 49(12): 25-31
Epidemiological study of the morphogenetic relationship between adenoma and large intestinal cancer
An analysis of autopsy data from three departments of pathology in three countries differing in the prevalence of large intestinal cancers has confirmed that these cancers are related morphogenetically to adenomatous polyps (adenomas). The highest percentage of persons with adenomas occurred in a region where the prevalence of large intestinal cancer was also the highest. The segmental distribution of large adenomas in the colon correlated with that of cancer, although the frequency of adenomas in the rectum was low and could not explain the high risk of cancer arising in this segment. This indicates that adenomas either are less important in the pathogenesis of rectal cancer or undergo malignant change less commonly than do those in other portions of the large intestine. The high rate of hyperplasic polyps in the rectum correlated with rectal cancer morbidity, and hence it is suggested that although such polyps are not neoplasms, they nevertheless may serve as an indicator of increased risk of rectal cancer development.

Accession: 005375616

Related references

Immunohistochemical study on adenoma cancer in adenoma and advanced cancer of the large intestine using anti carcinoembryonic antigen monoclonal antibody with special reference to comparison with histochemical study of human colonic mucin. Stomach & Intestine (Tokyo) 20(2): 183-190, 1985

Epidemiologic study of the morphogenetic relation between adenoma and cancer of the colon. Arkhiv Patologii 49(12): 25-31, 1987

Changes in the index of atypia in large intestinal adenoma and cancer --an objective pathological diagnosis. Gan No Rinsho. Japan Journal of Cancer Clinics Spec No: 109-126, 1989

The relationship between diet, alcohol, and colorectal cancer. The results of a large-scale, eight-year, population-based, clinicopathological and epidemiological study conducted in Melbourne, Australia. Nutrition and Cancer 9(1): 1-56, 1987

Epidemiological Study of Colorectal Adenoma and Cancer in Symptomatic Patients in China between 199 and 29. 2011

Epidemiological study of colorectal adenoma and cancer in symptomatic patients in China between 1990 and 2009. Journal of Digestive Diseases 12(5): 371-378, 2012

Histogenesis of large intestinal adenoma as the origin of carcinoma of the large intestine in nonpolyposis coli. Gastroenterologia Japonica: 401, 1980

Genetic-epidemiologic study of adenoma and cancer of the large intestine. Genetika 35(4): 516-523, 1999

Cancer of the colon study of its radiological detection and of the adenoma cancer relationship by the systematic double contrast method 9000 examinations. Union Medicale du Canada 99(1): 95-99, 1970

Pattern of epithelial cell proliferation in colorectal mucosa of patients with large bowel adenoma or cancer: an ECP case-control study. European cancer prevention. European Journal of Cancer Prevention 8(5): 401-407, 1999