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Epidemiological study on the estimation of the effects of smoking and respiratory symptoms and diseases using values of salivary albumin immuno globulin a and immuno globulin g


, : Epidemiological study on the estimation of the effects of smoking and respiratory symptoms and diseases using values of salivary albumin immuno globulin a and immuno globulin g. Yokohama Medical Journal 33(1): 63-80

Concentrations of Ig A, Ig G and albumin in saliva or sputa collected from 330 school children, 152 junior high school students, 334 adult people and 80 patients with chronic obstructive pulmonary disease were examined. Concentrations of Ig A and albumin in saliva were increased with the advance in age up to 20 yr old. There were differences in these concentrations between male and female adults over 20 yr old. Significantly decreased concentrations of Ig A and positive rates of Ig G were found in smokers for more than 20 yr compared with nonsmokers. Concentrations of Ig A in saliva were higher in the subjects complaining of persistent cough or phlegm than the healthy subjects. But, significantly decreased concentrations of Ig A were found in the patients with chronic bronchitis and bronchial asthma compaired with the healthy subjects. In the patients with bronchial asthma, the decreasing concentrations of Ig A in saliva were observed following prolongation of clinical symptoms. Especially, in the cases of 3rd group (suffering over 10 yr) a marked decrease of Ig A content in saliva was noted. Concentrations of Ig A in sputa and saliva of the patients with bronchial asthma were elevated as frequency of cough and phlegm increased.

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