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Epidemiological survey of hepatitis b virus infection in chiang mai thailand 1981 1982


, : Epidemiological survey of hepatitis b virus infection in chiang mai thailand 1981 1982. Journal of Nippon Medical School 52(1): 3-9

School children (59) at Wat Kau Khum (WKK) School, Chiang Mai Province, and 52 children and their parents under the care of the Comprehensive Child Care Clinic (CCCC), Chiang Mai University were tested for HBsAg [hepatitis B surface antigen] and anti-HBc [antibody to HB core antigen] in their blood. Eighteen HBsAg-positive specimens were tested also for HBeAg [e antigen] and anti-HBe. Determinations of the HBV-serological markers were done by using the enzyme-linked immunosorbent assay (ELISA). HBsAg was found in 27.0% (17/63) of the children at WKK, in 7.6% (4/53) of the children and 5.4% (3/56) of the parents at CCCC. Twenty percent (3/15) of HBsAg-positive children at WKK were HBeAg-positive. Anti-HBc was positive in 45.0% of the children at WKK and in 47.3 to 52.0% of the children and parents at CCCC, but percentages of anti-HBc positive were estimated at 86.7% for WKK and 84.6 to 93.9% for CCCC, if border-line values were referred to as positive. Study on paired sera from children and parents at CCCC revealed that 92.0% (46/50) of the children from HBsAg-negative parents were free from the antigen, and 68.0% (17/25) of the children from anti-HBc-positive parents were positive for the antibody, whereas only 20.0% (1/5) of the children from anti-HBc-negative parents had the antibody.

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