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Epidemiology and treatment of tinea capitis: ketoconazole vs. griseofulvin

, : Epidemiology and treatment of tinea capitis: ketoconazole vs. griseofulvin. Pediatric Infectious Disease Journal 6(1): 46-49

We studied 80 children with tinea capitis without kerion to define the epidemiology and clinical characteristics of tinea capitis and to compare the therapeutic efficacy of griseofulvin and ketoconazole for treatment of this disorder. Patients ranged in age from 2.1 to 11 years (median, 5.2 years). Trichophyton tonsurans (74%), Microsporum canis (13.5%) and Trichophyton mentagrophytes (2.7%) accounted for 90% of the infections. Pretreatment KOH slide preparations were positive in 69% of patients with alopecia and in only 29% of those with diffuse scale with little hair loss. Sixty-three patients were randomly assigned to receive ketoconazole (5 mg/kg/day) or griseofulvin (15 mg/kg/day). The treatment groups were comparable with regard to age, sex, duration of lesions prior to treatment and type of lesions. The percent of patients with positive cultures on therapy at 4, 6, 8, and 10 weeks and the mean time to a sterile culture were significantly larger (P less than 0.01) in ketoconazole (8 weeks) than in griseofulvin-treated (4 weeks) patients. The time for complete scalp clearing was significantly longer in patients who received ketoconazole (median, 108 days) compared with those who were treated with griseofulvin (median, 60 days) (P = 0.01).

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Accession: 005375828

PMID: 3822616

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Related references

Tanz, R.R.; Stagl, S.; Esterly, N.B., 1985: Comparison of ketoconazole and griseofulvin for treatment of tinea capitis in childhood: a preliminary study. Treatment of children with tinea capitis currently consists of griseofulvin given orally for 1 to 3 months. Ketoconazole, a newer antifungal, is effective therapy for a variety of systemic mycoses. A randomized double-blind, placebo-controlled stu...

Tanz, R.R.; Hebert, A.A.; Esterly, N.B., 1988: Treating tinea capitis: should ketoconazole replace griseofulvin?. We undertook a randomized double-blind comparison of griseofulvin and ketoconazole for the treatment of tinea capitis. The outcome was based on fungal culture results and changes in clinical signs and symptoms determined by an assessment system th...

Couatarmanac'h A.; Mignard M.H.; Guiguen C.; Aznar C.; Chevrant Breton J., 1989: Chronic trichophyton mentagrophytes tinea capitis prolonged by griseofulvin and ketoconazole cured by itraconazole. A 2-year old child in good health, presented a T. mentagrophytes tinea Capitis recalcitrant to therapy by ketoconazole: 5 mg/Kg/d during 2 months and griseofulvin: 20 mg/Kg/d during 11 months and 25 mg/Kg/d during 5 months. The recovery was obtain...

Porto, J.A., 1961: Tinea capitis. Treatment with griseofulvin. Jornal de Pediatria 26: 385-397

Crissey, J.T.; Olmstead, C.B., 1961: Griseofulvin in the treatment of tinea capitis. New York State Journal of Medicine 61: 3629-3631

Meenan, F.O., 1961: The treatment of tinea capitis with griseofulvin. St. Anne's and the Children's Hosp., Dublin; 27 cases, in children (2-12 yr.) (Microsporum audouinii 15, M. canis 5, Trichophyton tonsurans 6, T.

Elewski, B.E., 1999: Treatment of tinea capitis: beyond griseofulvin. Tinea capitis is a common pediatric scalp infection caused by dermatophytes. Topical therapy alone is ineffective, so oral griseofulvin has traditionally been the standard treatment. The new antimycotic agents itraconazole, terbinafine, and flucon...

Zackheim, H.S., 1961: Treatment of tinea capitis with griseofulvin. Journal - Michigan State Medical Society 60: 1189-1192

Neves, H.; Cabral, A.; Nunes, F.; Caldeira, B., 1963: Intermittent treatment of tinea capitis with griseofulvin. It is reported from the Central Dept Health, Lisbon, that while the great majority of 109 cases of tinea capitis (Microsporum canis, Trichophyton violaceum, T. tonsurans) were cured by, .either standard or fine-particle griseofulvin at a variety o...

Bouvy, L.E.; Pattyn, S.R., 1960: Treatment of tinea capitis by means of griseofulvin. Elizabethville, Belgian Congo; 25 cases (Microsporum audouinii, Trichophyton violaceum, T. ferrugineum. A T.