EurekaMag.com logo
+ Translate

Epidemiology of bladder exstrophy and epispadias: a communication from the International Clearinghouse for Birth Defects Monitoring Systems


, : Epidemiology of bladder exstrophy and epispadias: a communication from the International Clearinghouse for Birth Defects Monitoring Systems. Teratology 36(2): 221-227

A study of infants with bladder exstrophy or epispadias was based on data from ten malformation monitoring systems around the world. The material is derived from nearly 6.3 million births. The recorded prevalence at birth of bladder exstrophy was 3.3 per 100,000 births and of epispadias (without bladder exstrophy) 2.4 per 100,000. The recorded rates of bladder exstrophy did not vary between the monitoring systems, but the rates of epispadias did. Furthermore, nearly all registered infants with epispadias were males. The sex ratio for bladder exstrophy was 1.5:1. Perinatal deaths occurred mainly when other malformations were also present. There was an increased risk in this group of malformations in infants of women aged less than 20 years. At high parity (3+), an increased risk was observed for bladder exstrophy, but there was a decreased risk for epispadias. The birth weight distribution was shifted slightly more to the left in isolated bladder exstrophy than in isolated epispadias, but was considerably shifted to the left when other malformations existed with bladder exstrophy. Most infants with other malformations belonged to the cloacal exstrophy sequence. There was no definite time trend between 1970 and 1985 in the prevalence at birth of bladder exstrophy. The study demonstrates how data from different monitoring registries can be pooled to characterize a rare malformation.

Accession: 005375919

PMID: 3424208

DOI: 10.1002/tera.1420360210

Download PDF Full Text: Epidemiology of bladder exstrophy and epispadias: a communication from the International Clearinghouse for Birth Defects Monitoring Systems


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Related references

Siffel, C.; Correa, A.; Amar, E.; Bakker, M.K.; Bermejo-Sánchez, E.; Bianca, S.; Castilla, E.E.; Clementi, M.; Cocchi, G.; Csáky-Szunyogh, M.; Feldkamp, M.L.; Landau, D.; Leoncini, E.; Li, Z.; Lowry, R.Brian.; Marengo, L.K.; Mastroiacovo, P.; Morgan, M.; Mutchinick, O.M.; Pierini, A.; Rissmann, A.; Ritvanen, A.; Scarano, G.; Szabova, E.; Olney, R.S., 2012: Bladder exstrophy: an epidemiologic study from the International Clearinghouse for Birth Defects Surveillance and Research, and an overview of the literature. Bladder exstrophy (BE) is a complex congenital anomaly characterized by a defect in the closure of the lower abdominal wall and bladder. We aimed to provide an overview of the literature and conduct an epidemiologic study to describe the prevalenc...

E.Al, 1981: A communication from the international clearinghouse for birth defects monitoring system. International Journal Of Epidemiology: 245-246

Flynt J.W., 1977: International clearinghouse for birth defects monitoring systems. Teratology 16(3): 366

Robert, J.M.; Robert, E.; Francannet, C., 1986: International Clearinghouse for Birth Defects Monitoring Systems (ICBDMS). An example of effective international cooperation. Archives Francaises de Pediatrie 43(7): 539-541

Rosano, A.; Botto, L.D.; Olney, R.S.; Khoury, M.J.; Ritvanen, A.; Goujard, J.; Stoll, C.; Cocchi, G.; Merlob, P.; Mutchinick, O.; Cornel, M.C.; Castilla, E.E.; Martínez-Frías, M.L.; Zampino, G.; Erickson, J.D.; Mastroiacovo, P., 2000: Limb defects associated with major congenital anomalies: clinical and epidemiological study from the International Clearinghouse for Birth Defects Monitoring Systems. Although limb defects associated with other congenital anomalies are rarely studied, they may provide insights into limb development that may be useful for etiologic studies and public health monitoring. We pooled data from 11 birth defect registr...

Rosano, A.; Botto, L.D.; Olney, R.S.; Khoury, M.J.; Ritvanen, A.; Goujard, J.; Stoll, C.; Cocchi, G.; Merlob, P.; Mutchinick, O.; Cornel, M.C.; Castilla, E.E.; Martinez Frias, M.L.isa; Zampino, G.; Erickson, J.D.vid; Mastroiacovo, P., 2000: Limb defects associated with major congenital anomalies: Clinical and epidemiological study from the International Clearinghouse for Birth Defects Monitoring Systems. Although limb defects associated with other congenital anomalies are rarely studied, they may provide insights into limb development that may be useful for etiologic studies and public health monitoring. We pooled data from 11 birth defect registr...

Erickson, J.D., 1991: The International Clearinghouse for Birth Defects Monitoring Systems: Past, present and future. The International Clearinghouse for Birth Defects Monitoring Systems (ICBDMS), founded in 1974, is an organization devoted to the prevention of birth defects. A major activity of member programs is the monitoring of rates of birth defects, searchi...

Anonymous, 2003: International Clearinghouse for Birth Defect Monitoring Systems and National Birth Defects Prevention Network Collaborative Meeting, Atlanta, GA, USA, September, 20, 2002. This meeting contains 19 abstracts of oral presentations and 28 abstracts of poster presentations in English. The topics covered include alcohol consumption in pregnant and postpartum women, neural tube defects, use of data collected via monitorin...

Anonymous, 2003: International Clearinghouse for Birth Defect Monitoring Systems (ICBDMS) and National Birth Defects Prevention Network (NBDPN) Collaborative Meeting, Atlanta, GA, USA, September, 20, 2002. This meeting contains 19 abstracts of oral presentations and 28 abstracts of poster presentations in English. The topics covered include alcohol consumption in pregnant and postpartum women, neural tube defects, use of data collected via monitorin...

Feldkamp, M.L.; Botto, L.D.; Amar, E.; Bakker, M.K.; Bermejo-Sánchez, E.; Bianca, S.; Canfield, M.A.; Castilla, E.E.; Clementi, M.; Csaky-Szunyogh, M.; Leoncini, E.; Li, Z.; Lowry, R.Brian.; Mastroiacovo, P.; Merlob, P.; Morgan, M.; Mutchinick, O.M.; Rissmann, A.; Ritvanen, A.; Siffel, C.; Carey, J.C., 2012: Cloacal exstrophy: an epidemiologic study from the International Clearinghouse for Birth Defects Surveillance and Research. Cloacal exstrophy presents as a complex abdominal wall defect thought to result from a mesodermal abnormality. Anatomically, its main components are Omphalocele, bladder Exstrophy and Imperforate anus. Other associated malformations include renal...