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Equine laminitis part 2 elevation in serum testosterone associated with induced and naturally occurring laminitis

Equine laminitis part 2 elevation in serum testosterone associated with induced and naturally occurring laminitis

Journal of Equine Medicine & Surgery 3(4): 171-175

Serum testosterone [T] levels were determined by radioimmunoassay on samples collected at 4 h intervals from 10 horses that were fed a high carbohydrate diet to induce laminitis. Eight developed symptoms, one did not and one died within 24 h postadministration of the carbohydrate load. All horses with symptoms had elevated levels of serum T 4-8 h prior to the time of diagnosis. These horses, all mares or geldings, had a mean pretreatment serum T concentration of 50 pg/ml. Mean T concentration 4 h prior to development of symptoms had risen to 159 pg/ml. The relationship to a possible adrenal-stress phenomenon is considered. In addition, 10 of 12 mares and geldings presented to a large animal clinic with laminitis had elevated serum levels of T.

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Accession: 005380146

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